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NCT07651787 · ClinicalTrials.gov registry record · NA
Using Light Therapy for Mild Cognitive Impairment
A NA study, sponsored by University of Oklahoma.
- Recruiting
- Registry status
- NA
- Development phase
- 40
- Enrollment target
NCT07651787: Recruiting NA study, sponsored by University of Oklahoma.
NCT07651787 is a NA study that is actively recruiting participants, run by University of Oklahoma. The registered enrollment target is 40 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07651787, a NA study, is actively recruiting participants, sponsored by University of Oklahoma.
- RECRUITING
- Registry status
- NA
- Development phase
- 40 participants
- Enrollment target
Study Summary
The goal of this clinical trial is to test whether transcranial photobiomodulation (tPBM), a non-invasive brain stimulation technique using near-infrared light, can improve brain blood flow regulation (neurovascular coupling) and cognitive function in people with mild cognitive impairment (MCI). The main questions it aims to answer are: * Does tPBM enhance cognitive function and cerebral hemodynamic responses during memory and finger tapping tasks? * Does tPBM reduce oxidative stress, inflammation, and mitigate brain cell damage? * Is cognitive improvement linked to amyloid status, greater cerebral hemodynamic response, and lower levels of brain inflammation and oxidative stress? Researchers will compare an active tPBM treatment arm to a sham treatment arm to see if tPBM leads to measurable improvements in brain activity and cognitive function compared to no active stimulation. Participants will: * Receive a 20-minute-long active tPBM or sham stimulation session once per day, 6 times per week, for 12 weeks. * Complete questionnaires and an iPad-based cognitive testing protocol. * Complete memory and motor tasks while their brain activity is measured using non-invasive techniques: simultaneous functional near-infrared spectroscopy (fNIRS) and electroencephalography (EEG). Dynamic analysis of the vessels in the eye will also be performed based on eligibility. Transcranial Doppler (TCD) flowmetry is optionally performed. * Provide blood samples to test for biomarkers of inflammation, oxidative stress, and brain cell damage.
Primary Outcome
Functional near infrared spectroscopy (fNIRS) and electroencephalography (EEG) will be performed during the cognitive n-back task. fNIRS approach generates data that represent a relative change in oxygenated and deoxygenated hemoglobin measured over the cortical brain tissues. EEG records electrical potential changes in the brain cortex. Neurovascular coupling will be evaluated as a change in oxy- and deoxy-hemoglobin between before and after treatment, normalized to change in EEG. The change in
Interventions
- DEVICE Active Vielight Neuro RX-Duo device -Active transcranial photobiomodulation
- DEVICE Sham Vielight Neuro RX-Duo device -Sham transcranial photobiomodulation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2025-10-01 |
| Est. Completion | 2026-12-31 |
| Phase | NA |
What NCT07651787 shows while recruiting
NCT07651787 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 2 interventions - of which Active Vielight Neuro RX-Duo device -Active transcranial photobiomodulation is the first listed.
NCT07651787 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07651787 about?
NCT07651787 is a clinical study titled "Using Light Therapy for Mild Cognitive Impairment". The goal of this clinical trial is to test whether transcranial photobiomodulation (tPBM), a non-invasive brain stimulation technique using near-infrared light, can improve brain blood flow regulation (neurovascular coupling) and cognitive function in people with mild cognitive impairment (MCI). The...
What is the current status of trial NCT07651787?
This trial is currently recruiting. It is a NA study. The enrollment target is 40 participants. The study started on 2025-10-01. Estimated completion is 2026-12-31.
What interventions are being tested in trial NCT07651787?
The interventions under investigation include: Active Vielight Neuro RX-Duo device -Active transcranial photobiomodulation (DEVICE), Sham Vielight Neuro RX-Duo device -Sham transcranial photobiomodulation (DEVICE).
Who is sponsoring clinical trial NCT07651787?
This trial is sponsored by University of Oklahoma, which has 358 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07651787's enrollment target sits among peer trials
40 1447th of 2000 higher than 465 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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