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NCT07650656 · ClinicalTrials.gov registry record · Phase 2
Fluorescence-Guided Surgical Resection for Reducing Unexpected Positive Margins in Patients With Sarcoma, SarcoSIGHT Trial
A Phase 2 study, sponsored by City of Hope Medical Center.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 22
- Enrollment target
NCT07650656 is a Phase 2 study that is actively recruiting participants, run by City of Hope Medical Center. The registered enrollment target is 22 participants.
The verdict
NCT07650656, a Phase 2 study, is actively recruiting participants, sponsored by City of Hope Medical Center.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 22 participants
- Enrollment target
Study Summary
This phase II trial compares standard of care surgical resection to fluorescence-guided surgical resection using indocyanine green and fluorescence imaging for reducing unexpected positive margin rates in patients with sarcoma. Surgical margins are one of the criteria used in assessing the effectiveness of a given surgical procedure. They are the edges or border of the tissue removed in cancer surgery. A negative margin means that the resected tumor is surrounded by normal tissue, which implies there is no disease left in the patient. By contrast, a positive margin means that sarcoma cells are visible at the edge of the tumor. Positive margins may be classified as planned when they are expected pre-operatively due to the preservation of a critical structure, or unexpected when the pathologist reports the presence of tumor at the margin despite the surgeon having intended to remove it in its entirety. Fluorescence-guided surgery is an established surgical method that involves the administration of fluorescent dye (in this case, indocyanine green) into the tumor, which can then be visualized with a special camera during surgery to help surgeons identify tumor versus healthy tissue. Fluorescence-guided surgery may reduce the rate of unexpected positive margins in patients undergoing surgery for sarcoma.
Interventions
- DRUG Indocyanine Green
- OTHER Questionnaire Administration
- OTHER Electronic Health Record Review
- PROCEDURE Fluorescence Imaging
- PROCEDURE Fluorescence-Guided Surgery
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 22 participants |
| Start Date | 2027-05-15 |
| Est. Completion | 2028-05-11 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07650656
The ClinicalTrials.gov registry entry for NCT07650656 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 22 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is City of Hope Medical Center, which has 582 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 5 interventions - of which Indocyanine Green is the first listed.
NCT07650656 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT07650656 about?
NCT07650656 is a clinical study titled "Fluorescence-Guided Surgical Resection for Reducing Unexpected Positive Margins in Patients With Sarcoma, SarcoSIGHT Trial". This phase II trial compares standard of care surgical resection to fluorescence-guided surgical resection using indocyanine green and fluorescence imaging for reducing unexpected positive margin rates in patients with sarcoma. Surgical margins are one of the criteria used in assessing the effective...
What is the current status of trial NCT07650656?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 22 participants. The study started on 2027-05-15. Estimated completion is 2028-05-11.
What interventions are being tested in trial NCT07650656?
The interventions under investigation include: Indocyanine Green (DRUG), Questionnaire Administration (OTHER), Electronic Health Record Review (OTHER), Fluorescence Imaging (PROCEDURE), Fluorescence-Guided Surgery (PROCEDURE).
Who is sponsoring clinical trial NCT07650656?
This trial is sponsored by City of Hope Medical Center, which has 582 total clinical trials registered on ClinicalTrials.gov.
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