Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT07646054 · ClinicalTrials.gov registry record · NA
Digital Lifestyle Coaching for Alzheimer's Disease Prevention in APOE4 Carriers
A NA study, sponsored by Scripps Translational Science Institute.
- Not yet
- Registry status
- NA
- Development phase
- 1,200
- Enrollment target
NCT07646054 is a NA study that has not yet begun recruiting, run by Scripps Translational Science Institute. The registered enrollment target is 1,200 participants.
The verdict
NCT07646054, a NA study, has not yet begun recruiting, sponsored by Scripps Translational Science Institute.
- NOT YET RECRUITING
- Registry status
- NA
- Development phase
- 1,200 participants
- Enrollment target
Study Summary
Wellderly Brain is a randomized, direct-to-participant trial evaluating whether a virtually delivered, multidomain lifestyle coaching intervention can favorably impact plasma biomarkers of Alzheimer's disease (AD) in adults aged 60-80 with APOE4 positivity or elevated polygenic risk. Participants are recruited through 23andMe and enrolled via the MyDataHelps platform. Following genetic eligibility screening, 1,200 participants will be randomized to either a digital lifestyle coaching arm (UCardia) or an education-only control arm. The intervention consists of 16 virtual coaching sessions delivered over 52 weeks. All participants will wear an Oura Ring for continuous health monitoring and provide dried blood samples at baseline, 6 months, and 12 months for plasma p-tau217 and proteomic profiling via the NULISAseq CNS Disease Panel. Saliva samples will be collected for epigenetic aging analysis. The study duration is 14-16 months per participant.
Interventions
- BEHAVIORAL Education
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,200 participants |
| Start Date | 2026-07-06 |
| Est. Completion | 2028-12-31 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07646054
The ClinicalTrials.gov registry entry for NCT07646054 describes a study currently listed as not yet recruiting, categorized as NA. The registered enrollment target is 1,200 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Scripps Translational Science Institute, which has 41 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Education is the first listed.
NCT07646054 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT07646054 about?
NCT07646054 is a clinical study titled "Digital Lifestyle Coaching for Alzheimer's Disease Prevention in APOE4 Carriers". Wellderly Brain is a randomized, direct-to-participant trial evaluating whether a virtually delivered, multidomain lifestyle coaching intervention can favorably impact plasma biomarkers of Alzheimer's disease (AD) in adults aged 60-80 with APOE4 positivity or elevated polygenic risk. Participants ar...
What is the current status of trial NCT07646054?
This trial is currently not yet recruiting. It is a NA study. The enrollment target is 1,200 participants. The study started on 2026-07-06. Estimated completion is 2028-12-31.
What interventions are being tested in trial NCT07646054?
The interventions under investigation include: Education (BEHAVIORAL).
Who is sponsoring clinical trial NCT07646054?
This trial is sponsored by Scripps Translational Science Institute, which has 41 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
Explore more on PlainTrial
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.