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NCT07646054 · ClinicalTrials.gov registry record · NA
Digital Lifestyle Coaching for Alzheimer's Disease Prevention in APOE4 Carriers
A NA study, sponsored by Scripps Translational Science Institute.
- Not yet
- Registry status
- NA
- Development phase
- 1,200
- Enrollment target
NCT07646054: Clinical Trial NA study, sponsored by Scripps Translational Science Institute.
NCT07646054 is a NA study that has not yet begun recruiting, run by Scripps Translational Science Institute. The registered enrollment target is 1,200 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (15% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07646054, a NA study, has not yet begun recruiting, sponsored by Scripps Translational Science Institute.
- NOT YET RECRUITING
- Registry status
- NA
- Development phase
- 1,200 participants
- Enrollment target
Study Summary
Wellderly Brain is a randomized, direct-to-participant trial evaluating whether a virtually delivered, multidomain lifestyle coaching intervention can favorably impact plasma biomarkers of Alzheimer's disease (AD) in adults aged 60-80 with APOE4 positivity or elevated polygenic risk. Participants are recruited through 23andMe and enrolled via the MyDataHelps platform. Following genetic eligibility screening, 1,200 participants will be randomized to either a digital lifestyle coaching arm (UCardia) or an education-only control arm. The intervention consists of 16 virtual coaching sessions delivered over 52 weeks. All participants will wear an Oura Ring for continuous health monitoring and provide dried blood samples at baseline, 6 months, and 12 months for plasma p-tau217 and proteomic profiling via the NULISAseq CNS Disease Panel. Saliva samples will be collected for epigenetic aging analysis. The study duration is 14-16 months per participant.
Primary Outcome
Plasma phosphorylated tau 217 (pTau217) concentration will be measured from self-collected dried blood spot samples at three timepoints across the 12-month active monitoring period. Both absolute concentration at each time point and change from baseline will be assessed.
Interventions
- BEHAVIORAL Education
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,200 participants |
| Start Date | 2026-07-06 |
| Est. Completion | 2028-12-31 |
| Phase | NA |
What is known before NCT07646054 opens enrollment
NCT07646054 is an interventional study that assigns participants to a tested intervention. Its 1,200 participants enrollment target places it among the larger protocols in the corpus, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (15% lower).
The record links to 0 conditions, and to 1 intervention - of which Education is the first listed.
NCT07646054 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07646054 about?
NCT07646054 is a clinical study titled "Digital Lifestyle Coaching for Alzheimer's Disease Prevention in APOE4 Carriers". Wellderly Brain is a randomized, direct-to-participant trial evaluating whether a virtually delivered, multidomain lifestyle coaching intervention can favorably impact plasma biomarkers of Alzheimer's disease (AD) in adults aged 60-80 with APOE4 positivity or elevated polygenic risk. Participants ar...
What is the current status of trial NCT07646054?
This trial is currently not yet recruiting. It is a NA study. The enrollment target is 1,200 participants. The study started on 2026-07-06. Estimated completion is 2028-12-31.
What interventions are being tested in trial NCT07646054?
The interventions under investigation include: Education (BEHAVIORAL).
Who is sponsoring clinical trial NCT07646054?
This trial is sponsored by Scripps Translational Science Institute, which has 41 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07646054's enrollment target sits among peer trials
1,200 83rd of 2000 higher than 1,912 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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