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NCT07638046 · ClinicalTrials.gov registry record · Phase 2
Mindful Walking Neural Correlates of Executive Function in SC Older Adults at Risk of Dementias
A Phase 2 study, sponsored by University of South Carolina.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 54
- Enrollment target
NCT07638046: Recruiting Phase 2 study, sponsored by University of South Carolina.
NCT07638046 is a Phase 2 study that is actively recruiting participants, run by University of South Carolina. The registered enrollment target is 54 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (59% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07638046, a Phase 2 study, is actively recruiting participants, sponsored by University of South Carolina.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 54 participants
- Enrollment target
Study Summary
Mindful walking is a promising and practical strategy because it combines two activities known to support healthy aging: walking and mindfulness. Unlike many structured exercise programs, mindful walking is low intensity, accessible, and easier to sustain in daily life. It may be especially useful for older adults at elevated risk for ADRD. However, most existing mindful walking studies have focused on mental health outcomes, such as stress reduction, rather than cognitive health. Little is known about whether mindful walking can support cognition or how it may influence brain function. To address this gap and strengthen a future R01 resubmission, the investigators propose a two-arm randomized controlled pilot trial using functional near-infrared spectroscopy (fNIRS), a safe, non-invasive brain imaging method. fNIRS measures brain activity through sensors placed on the scalp and is well-suited for repeated assessments in older adults because it is quiet, portable, painless, and cost-effective. The investigators will recruit racially and ethnically diverse middle-aged and older adults from the Midlands of South Carolina who are at elevated risk for ADRD. Participants will be randomly assigned to one of two groups: mindful walking or walking-only control. Both groups will complete 8 staff-supervised individual sessions over 4 weeks. The mindful walking group will learn and practice simple mindfulness skills while walking in multiple settings, including lab-based, indoor, and outdoor environments, to support real-world use. Findings from this pilot study will provide important evidence on whether mindful walking can support brain and cognitive health in adults at elevated risk for ADRD. The results will also help establish a practical, scalable, and sustainable prevention strategy for underserved aging populations in South Carolina.
Primary Outcome
Hemodynamic activation in the prefrontal and parietal regions as an indication of EF. Neural activation will be measured using functional nearinfrared spectroscopy (fNIRS).
Interventions
- BEHAVIORAL Mindfulness-based walking
- BEHAVIORAL Walking-only
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 54 participants |
| Start Date | 2026-06-26 |
| Est. Completion | 2027-11-17 |
| Phase | Phase 2 |
What NCT07638046 shows while recruiting
NCT07638046 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 54 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (59% lower).
The record links to 0 conditions, and to 2 interventions - of which Mindfulness-based walking is the first listed.
NCT07638046 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07638046 about?
NCT07638046 is a clinical study titled "Mindful Walking Neural Correlates of Executive Function in SC Older Adults at Risk of Dementias". Mindful walking is a promising and practical strategy because it combines two activities known to support healthy aging: walking and mindfulness. Unlike many structured exercise programs, mindful walking is low intensity, accessible, and easier to sustain in daily life. It may be especially useful f...
What is the current status of trial NCT07638046?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 54 participants. The study started on 2026-06-26. Estimated completion is 2027-11-17.
What interventions are being tested in trial NCT07638046?
The interventions under investigation include: Mindfulness-based walking (BEHAVIORAL), Walking-only (BEHAVIORAL).
Who is sponsoring clinical trial NCT07638046?
This trial is sponsored by University of South Carolina, which has 157 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07638046's enrollment target sits among peer trials
54 1160th of 2000 higher than 830 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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