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NCT07633704 · ClinicalTrials.gov registry record · NA
Protective Effect of Exercise on Acute High-fat Overfeeding
A NA study, sponsored by George Washington University.
- Completed
- Registry status
- NA
- Development phase
- 50
- Enrollment target
NCT07633704 is a NA study that has completed, run by George Washington University. The registered enrollment target is 50 participants.
The verdict
NCT07633704, a NA study, has completed, sponsored by George Washington University.
- COMPLETED
- Registry status
- NA
- Development phase
- 50 participants
- Enrollment target
Study Summary
Metabolic flexibility is the ability to switch rapidly from one substrate (i.e. fuel source) to another (e.g. fats to carbohydrates) in response to ingested foods. Worse metabolic flexibility is linked to worse metabolic outcomes, but exercise is thought to be protective against nutrient excess. We will conduct a standard oral glucose tolerance test (OGTT) to assess insulin resistance and metabolic flexibility. Participants will be randomized to a 24-hour hypercaloric, high-fat diet (HFD) with and without an exercise bout. During the hypercaloric HFD, participants will eat extra calories with more calories from fat than normal, which is expected to increase insulin resistance. After each arm of the high-fat diet, we will repeat the OGTT. During each OGTT, expired gases will be analyzed noninvasively to determine metablic flexibility. Insulin resistance will be determined with blood drawn during each OGTT. By comparing metabolic flexiblity and insulin resistance before and after the normal diet and after the high-fat diet intervention, a better understanding of how insulin resistance affects metabolism and how exercise can be protective will be developed.
Interventions
- BEHAVIORAL High Fat Overfeeding
- BEHAVIORAL High Fat Overfeeding + Exercise
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2025-02-10 |
| Est. Completion | 2026-04-09 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07633704
The ClinicalTrials.gov registry entry for NCT07633704 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 50 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is George Washington University, which has 133 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which High Fat Overfeeding is the first listed.
NCT07633704 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT07633704 about?
NCT07633704 is a clinical study titled "Protective Effect of Exercise on Acute High-fat Overfeeding". Metabolic flexibility is the ability to switch rapidly from one substrate (i.e. fuel source) to another (e.g. fats to carbohydrates) in response to ingested foods. Worse metabolic flexibility is linked to worse metabolic outcomes, but exercise is thought to be protective against nutrient excess. We ...
What is the current status of trial NCT07633704?
This trial is currently completed. It is a NA study. The enrollment target is 50 participants. The study started on 2025-02-10. Estimated completion is 2026-04-09.
What interventions are being tested in trial NCT07633704?
The interventions under investigation include: High Fat Overfeeding (BEHAVIORAL), High Fat Overfeeding + Exercise (BEHAVIORAL).
Who is sponsoring clinical trial NCT07633704?
This trial is sponsored by George Washington University, which has 133 total clinical trials registered on ClinicalTrials.gov.
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