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NCT07633704 · ClinicalTrials.gov registry record · NA
Protective Effect of Exercise on Acute High-fat Overfeeding
A NA study, sponsored by George Washington University.
- Completed
- Registry status
- NA
- Development phase
- 50
- Enrollment target
NCT07633704: Completed NA study, sponsored by George Washington University.
NCT07633704 is a NA study that has completed, run by George Washington University. The registered enrollment target is 50 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07633704, a NA study, has completed, sponsored by George Washington University.
- COMPLETED
- Registry status
- NA
- Development phase
- 50 participants
- Enrollment target
Study Summary
Metabolic flexibility is the ability to switch rapidly from one substrate (i.e. fuel source) to another (e.g. fats to carbohydrates) in response to ingested foods. Worse metabolic flexibility is linked to worse metabolic outcomes, but exercise is thought to be protective against nutrient excess. We will conduct a standard oral glucose tolerance test (OGTT) to assess insulin resistance and metabolic flexibility. Participants will be randomized to a 24-hour hypercaloric, high-fat diet (HFD) with and without an exercise bout. During the hypercaloric HFD, participants will eat extra calories with more calories from fat than normal, which is expected to increase insulin resistance. After each arm of the high-fat diet, we will repeat the OGTT. During each OGTT, expired gases will be analyzed noninvasively to determine metablic flexibility. Insulin resistance will be determined with blood drawn during each OGTT. By comparing metabolic flexiblity and insulin resistance before and after the normal diet and after the high-fat diet intervention, a better understanding of how insulin resistance affects metabolism and how exercise can be protective will be developed.
Primary Outcome
Oral Glucose Insulin Sensitivity
Interventions
- BEHAVIORAL High Fat Overfeeding
- BEHAVIORAL High Fat Overfeeding + Exercise
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2025-02-10 |
| Est. Completion | 2026-04-09 |
| Phase | NA |
What the finished NCT07633704 record still lists
NCT07633704 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 2 interventions - of which High Fat Overfeeding is the first listed.
NCT07633704 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07633704 about?
NCT07633704 is a clinical study titled "Protective Effect of Exercise on Acute High-fat Overfeeding". Metabolic flexibility is the ability to switch rapidly from one substrate (i.e. fuel source) to another (e.g. fats to carbohydrates) in response to ingested foods. Worse metabolic flexibility is linked to worse metabolic outcomes, but exercise is thought to be protective against nutrient excess. We ...
What is the current status of trial NCT07633704?
This trial is currently completed. It is a NA study. The enrollment target is 50 participants. The study started on 2025-02-10. Estimated completion is 2026-04-09.
What interventions are being tested in trial NCT07633704?
The interventions under investigation include: High Fat Overfeeding (BEHAVIORAL), High Fat Overfeeding + Exercise (BEHAVIORAL).
Who is sponsoring clinical trial NCT07633704?
This trial is sponsored by George Washington University, which has 133 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07633704's enrollment target sits among peer trials
50 1279th of 2000 higher than 622 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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