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NCT07625150 · ClinicalTrials.gov registry record
FDG PET/MRI Imaging of Patellofemoral Joint Osteoarthritis
A clinical trial, sponsored by University of California, San Francisco.
- Recruiting
- Registry status
- 50
- Enrollment target
NCT07625150: Recruiting study, sponsored by University of California, San Francisco.
NCT07625150 is a clinical trial that is actively recruiting participants, run by University of California, San Francisco. The registered enrollment target is 50 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07625150 is actively recruiting participants, sponsored by University of California, San Francisco.
- RECRUITING
- Registry status
- 50 participants
- Enrollment target
Study Summary
This project aims to develop an \[18F\] fluorodeoxyglucose (FDG) positron emission tomography (PET) / magnetic resonance imaging (MRI) method to locate the painful inflammation in PFJ OA associated with joint loading. \[18F\] FDG PET/MRI is an emerging pain imaging approach with enhanced sensitivity to painful hypermetabolic inflammation through evaluation of intracellular glucose utilization rate via (\[18F\]FDG PET) and fine anatomy details (MRI). The investigative group has shown its promise in revealing previously unidentified or unspecified pain generators in various musculoskeletal pain conditions. The investigators have also demonstrated the feasibility of visualizing the structural changes between unloaded and loaded knee joints with MRI, which can be easily adopted in the current PET/MRI setting. The main challenge in the proposed \[18F\]FDG PET/MRI approach is to differentiate the normal uptake of FDG for metabolic changes by weight-bearing from abnormal changes indicating eventual pain aggravation by weight-bearing and knee-flexion. The investigators have garnered the following two aims to validate the proposed method by comparing unloaded and loaded knee imaging results between PFJ OA pain patients and asymptomatic, matched controls.
Primary Outcome
Comparison of FDG SUVmax between PFJ OA patients and asymptomatic controls across various tissue types (synovium, femur, tibia, meniscus, fat pad, and muscles) to identify hypermetabolic inflammation at pre-loading.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2025-02-19 |
| Est. Completion | 2028-02 |
What NCT07625150 shows while recruiting
NCT07625150 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 50 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT07625150 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07625150 about?
NCT07625150 is a clinical study titled "FDG PET/MRI Imaging of Patellofemoral Joint Osteoarthritis". This project aims to develop an \[18F\] fluorodeoxyglucose (FDG) positron emission tomography (PET) / magnetic resonance imaging (MRI) method to locate the painful inflammation in PFJ OA associated with joint loading. \[18F\] FDG PET/MRI is an emerging pain imaging approach with enhanced sensitivity...
What is the current status of trial NCT07625150?
This trial is currently recruiting. The enrollment target is 50 participants. The study started on 2025-02-19. Estimated completion is 2028-02.
Who is sponsoring clinical trial NCT07625150?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
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