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NCT07610655 · ClinicalTrials.gov registry record · NA
Effects of Transcutaneous Vagal Nerve Stimulation on Post-Surgical Return to Consciousness, Delirium, and Depression
A NA study, sponsored by Northwestern University.
- Recruiting
- Registry status
- NA
- Development phase
- 40
- Enrollment target
NCT07610655: Recruiting NA study, sponsored by Northwestern University.
NCT07610655 is a NA study that is actively recruiting participants, run by Northwestern University. The registered enrollment target is 40 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07610655, a NA study, is actively recruiting participants, sponsored by Northwestern University.
- RECRUITING
- Registry status
- NA
- Development phase
- 40 participants
- Enrollment target
Study Summary
This study will examine whether noninvasive, transcutaneous vagal nerve stimulation (tcVNS) can help restore consciousness in patients in the operating room and the Post Anesthesia Care Unit (PACU). The study will also investigate if tcVNS can expedite discharge from the PACU and examine whether tcVNS administerd in the PACU helps reduce delirium and depression after surgery. The study will also evaluate whether tcVNS speeds cognitive recovery from emergence of anesthesia and surgery.
Primary Outcome
Time in minutes to a Patient State Index (PSI) (Sedline Sedation Monitor) score of 85. The PSI is a quantitative score derived from 4 channel EEG monitoring of the frontal and prefrontal cortex for assessing level of consciousnes during sedation and general anesthesia. The score ranges from 0 (EEG supression) -100 (fully awake). A PSI range of 25-50 indicates optimal hypnotic state for general anesthesia
Interventions
- DEVICE Transcutaneous vagal nerve stimulation
- DEVICE Sham (No Treatment)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2026-04-23 |
| Est. Completion | 2029-05-31 |
| Phase | NA |
What NCT07610655 shows while recruiting
NCT07610655 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 2 interventions - of which Transcutaneous vagal nerve stimulation is the first listed.
NCT07610655 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07610655 about?
NCT07610655 is a clinical study titled "Effects of Transcutaneous Vagal Nerve Stimulation on Post-Surgical Return to Consciousness, Delirium, and Depression". This study will examine whether noninvasive, transcutaneous vagal nerve stimulation (tcVNS) can help restore consciousness in patients in the operating room and the Post Anesthesia Care Unit (PACU). The study will also investigate if tcVNS can expedite discharge from the PACU and examine whether tcV...
What is the current status of trial NCT07610655?
This trial is currently recruiting. It is a NA study. The enrollment target is 40 participants. The study started on 2026-04-23. Estimated completion is 2029-05-31.
What interventions are being tested in trial NCT07610655?
The interventions under investigation include: Transcutaneous vagal nerve stimulation (DEVICE), Sham (No Treatment) (DEVICE).
Who is sponsoring clinical trial NCT07610655?
This trial is sponsored by Northwestern University, which has 1,209 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07610655's enrollment target sits among peer trials
40 1447th of 2000 higher than 465 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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