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NCT07599592 · ClinicalTrials.gov registry record · Early Phase 1
Open Label Study for the Use of Low Intensity Focused Ultrasound for Essential Tremor
A Early Phase 1 study, sponsored by University of California, Los Angeles.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 20
- Enrollment target
NCT07599592: Recruiting Early Phase 1 study, sponsored by University of California, Los Angeles.
NCT07599592 is a Early Phase 1 study that is actively recruiting participants, run by University of California, Los Angeles. The registered enrollment target is 20 participants, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (62% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07599592, a Early Phase 1 study, is actively recruiting participants, sponsored by University of California, Los Angeles.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 20 participants
- Enrollment target
Study Summary
This open-label pilot study will evaluate the safety, tolerability, feasibility, and preliminary efficacy of repeated low-intensity focused ultrasound pulsation (LIFUP) targeting the ventral intermediate nucleus (Vim) of the thalamus in patients with Essential Tremor (ET). Twelve adults with clinically diagnosed ET will undergo six LIFUP treatment sessions over approximately two weeks using the BrainSonix BX Pulsar 1002 system. Tremor severity will be assessed using clinician-rated scales (TETRAS and FTM), patient-reported quality-of-life measures (QUEST), and objective accelerometry before and after treatment sessions, with additional follow-up visits at one and three months post-treatment. MRI scans will be performed at baseline and after the final treatment session to monitor safety. The study aims to characterize whether non-ablative focused ultrasound can safely and transiently modulate tremor-related thalamic circuits and provide preliminary evidence supporting future controlled trials of LIFUP for ET.
Primary Outcome
Accelerometric trackers will be used to quantify and track tremor severity at each study session.
Interventions
- DEVICE Low Intensity Focused Ultrasound (LIFU)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2026-05-01 |
| Est. Completion | 2027-06-01 |
| Phase | Early Phase 1 |
What NCT07599592 shows while recruiting
NCT07599592 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (62% lower).
The record links to 0 conditions, and to 1 intervention - of which Low Intensity Focused Ultrasound (LIFU) is the first listed.
NCT07599592 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07599592 about?
NCT07599592 is a clinical study titled "Open Label Study for the Use of Low Intensity Focused Ultrasound for Essential Tremor". This open-label pilot study will evaluate the safety, tolerability, feasibility, and preliminary efficacy of repeated low-intensity focused ultrasound pulsation (LIFUP) targeting the ventral intermediate nucleus (Vim) of the thalamus in patients with Essential Tremor (ET). Twelve adults with clinica...
What is the current status of trial NCT07599592?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 20 participants. The study started on 2026-05-01. Estimated completion is 2027-06-01.
What interventions are being tested in trial NCT07599592?
The interventions under investigation include: Low Intensity Focused Ultrasound (LIFU) (DEVICE).
Who is sponsoring clinical trial NCT07599592?
This trial is sponsored by University of California, Los Angeles, which has 897 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07599592's enrollment target sits among peer trials
20 1157th of 2000 higher than 710 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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