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NCT07594795 · ClinicalTrials.gov registry record · NA
Temporal Interference Methods for Non-invasive Deep Brain Stimulation, Study 1.3
A NA study, sponsored by Indiana University.
- Recruiting
- Registry status
- NA
- Development phase
- 30
- Enrollment target
NCT07594795: Recruiting NA study, sponsored by Indiana University.
NCT07594795 is a NA study that is actively recruiting participants, run by Indiana University. The registered enrollment target is 30 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07594795, a NA study, is actively recruiting participants, sponsored by Indiana University.
- RECRUITING
- Registry status
- NA
- Development phase
- 30 participants
- Enrollment target
Study Summary
This grant aims to develop a line of research using temporal interference (TI) electrical neurostimulation technology to understand the causal role of deep brain structures in cognition. In the short term, the investigators aim to validate and characterize the effects of TI on brain activity as measured by fMRI and demonstrate its ability to focally stimulate deep brain regions without affecting overlying cortex. In the longer term, investigators aim to use these data to resolve longstanding debates about the function of deeper brain regions and lay the foundation for future clinical applications of TI for treating addiction, Obsessive-Compulsive Disorder (OCD), Parkinson's disease, and other disorders involving deep brain dysfunction. The grant supports 2 distinct aims, each of which will be evaluated through a series of independent studies.
Primary Outcome
Brain activity in the dorsal anterior cingulate cortex will be measured using functional magnetic resonance imaging (fMRI) during temporal interference (TI) stimulation at 20 Hz compared to a selected comparison beat frequency. The comparison frequency will be in the 1-100 Hz range. Activity will be reported as the percent change in blood-oxygen-level-dependent (BOLD) signal, which reflects changes in neural activity. Higher BOLD values indicate stronger brain activation.
Interventions
- DEVICE Temporal Interference (TI) Electrical Stimulation - dACC 20 Hz TI Active
- DEVICE Temporal Interference (TI) Electrical Stimulation - dACC 20 Hz TI Sham
- DEVICE Temporal Interference (TI) Electrical Stimulation - dACC Comparison Frequency TI Active
- DEVICE Temporal Interference (TI) Electrical Stimulation - dACC Comparison Frequency TI Sham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2026-05-30 |
| Est. Completion | 2026-07-31 |
| Phase | NA |
What NCT07594795 shows while recruiting
NCT07594795 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 4 interventions - of which Temporal Interference (TI) Electrical Stimulation - dACC 20 Hz TI Active is the first listed.
NCT07594795 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07594795 about?
NCT07594795 is a clinical study titled "Temporal Interference Methods for Non-invasive Deep Brain Stimulation, Study 1.3". This grant aims to develop a line of research using temporal interference (TI) electrical neurostimulation technology to understand the causal role of deep brain structures in cognition. In the short term, the investigators aim to validate and characterize the effects of TI on brain activity as meas...
What is the current status of trial NCT07594795?
This trial is currently recruiting. It is a NA study. The enrollment target is 30 participants. The study started on 2026-05-30. Estimated completion is 2026-07-31.
What interventions are being tested in trial NCT07594795?
The interventions under investigation include: Temporal Interference (TI) Electrical Stimulation - dACC 20 Hz TI Active (DEVICE), Temporal Interference (TI) Electrical Stimulation - dACC 20 Hz TI Sham (DEVICE), Temporal Interference (TI) Electrical Stimulation - dACC Comparison Frequency TI Active (DEVICE), Temporal Interference (TI) Electrical Stimulation - dACC Comparison Frequency TI Sham (DEVICE).
Who is sponsoring clinical trial NCT07594795?
This trial is sponsored by Indiana University, which has 890 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07594795's enrollment target sits among peer trials
30 1593rd of 2000 higher than 299 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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