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NCT07593859 · ClinicalTrials.gov registry record · NA
Overcoming the Barriers to Effective Transcranial Temporal Interference Stimulation in Humans
A NA study, sponsored by Northeastern University.
- Recruiting
- Registry status
- NA
- Development phase
- 30
- Enrollment target
NCT07593859 is a NA study that is actively recruiting participants, run by Northeastern University. The registered enrollment target is 30 participants.
The verdict
NCT07593859, a NA study, is actively recruiting participants, sponsored by Northeastern University.
- RECRUITING
- Registry status
- NA
- Development phase
- 30 participants
- Enrollment target
Study Summary
Transcranial temporal interference stimulation (TIS) is an emerging novel tool for non-invasive transcranial brain stimulation that holds the potential for focal and steerable neuromodulation, and the possibility to stimulate focally at depth. TIS involves combining two high frequency waveforms to create a waveform with a "beat" frequency that is physiological relevant for neuromodulation. Successful applications to deep brain targets as well as steerability of the stimulation focus have been demonstrated in mice. Numerous recent investigations in humans have shown great clinical potential for this technology, however several questions about the basic mechanism of TIS action remain. The investigators will apply TIS to the motor cortex of humans and use established transcranial magnetic stimulation techniques to assess cortical excitability in relation to the phase of the TIS waveform. Using TMS, the investigators will i) validate that effects of TIS are due to the "beat" frequency and not the high frequency carrier signal, ii) evaluate the effect of the TIS carrier frequency, and iii) evaluate that whether changes in corticospinal excitability outlast the period of stimulation. Knowledge gained from this experiment will provide a basis for the future use of TIS for clinical applications, including informing parameter optimization.
Interventions
- DEVICE transcranial Temporal Interference Stimulation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2026-02-01 |
| Est. Completion | 2029-10-01 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07593859
The ClinicalTrials.gov registry entry for NCT07593859 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 30 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Northeastern University, which has 39 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which transcranial Temporal Interference Stimulation is the first listed.
NCT07593859 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT07593859 about?
NCT07593859 is a clinical study titled "Overcoming the Barriers to Effective Transcranial Temporal Interference Stimulation in Humans". Transcranial temporal interference stimulation (TIS) is an emerging novel tool for non-invasive transcranial brain stimulation that holds the potential for focal and steerable neuromodulation, and the possibility to stimulate focally at depth. TIS involves combining two high frequency waveforms to c...
What is the current status of trial NCT07593859?
This trial is currently recruiting. It is a NA study. The enrollment target is 30 participants. The study started on 2026-02-01. Estimated completion is 2029-10-01.
What interventions are being tested in trial NCT07593859?
The interventions under investigation include: transcranial Temporal Interference Stimulation (DEVICE).
Who is sponsoring clinical trial NCT07593859?
This trial is sponsored by Northeastern University, which has 39 total clinical trials registered on ClinicalTrials.gov.
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