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NCT07588152 · ClinicalTrials.gov registry record · Phase 4
Imaging the Effects of Netarsudil (Rhopressa) on the Trabecular Meshwork in Glaucoma and Ocular Hypertension
A Phase 4 study, sponsored by Indiana University.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 50
- Enrollment target
NCT07588152: Recruiting Phase 4 study, sponsored by Indiana University.
NCT07588152 is a Phase 4 study that is actively recruiting participants, run by Indiana University. The registered enrollment target is 50 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (90% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07588152, a Phase 4 study, is actively recruiting participants, sponsored by Indiana University.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 50 participants
- Enrollment target
Study Summary
This study evaluates the effects of netarsudil (Rhopressa) on the trabecular meshwork in subjects with ocular hypertension or open-angle glaucoma. Participants will be randomized to receive either netarsudil or placebo (artificial tears). High-resolution imaging using adaptive optics gonioscopy, anterior segment optical coherence tomography (AS-OCT), and OCT gonioscopy will be performed at baseline and after approximately 14 days of treatment. The primary objective is to assess changes in trabecular meshwork lamellae spacing, with secondary measures including trabecular meshwork height, width, and Schlemm's canal diameter.
Primary Outcome
Mean change in trabecular meshwork lamellae spacing measured using adaptive optics gonioscopy. Measurements will be obtained from baseline (after washout if applicable) and compared to measurements after treatment.
Interventions
- DRUG Netarsudil Ophthalmic Solution (Rhopressa)
- OTHER Artificial Tears (AT)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2026-06-05 |
| Est. Completion | 2028-06 |
| Phase | Phase 4 |
What NCT07588152 shows while recruiting
NCT07588152 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (90% lower).
The record links to 0 conditions, and to 2 interventions - of which Netarsudil Ophthalmic Solution (Rhopressa) is the first listed.
NCT07588152 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07588152 about?
NCT07588152 is a clinical study titled "Imaging the Effects of Netarsudil (Rhopressa) on the Trabecular Meshwork in Glaucoma and Ocular Hypertension". This study evaluates the effects of netarsudil (Rhopressa) on the trabecular meshwork in subjects with ocular hypertension or open-angle glaucoma. Participants will be randomized to receive either netarsudil or placebo (artificial tears). High-resolution imaging using adaptive optics gonioscopy, ant...
What is the current status of trial NCT07588152?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 50 participants. The study started on 2026-06-05. Estimated completion is 2028-06.
What interventions are being tested in trial NCT07588152?
The interventions under investigation include: Netarsudil Ophthalmic Solution (Rhopressa) (DRUG), Artificial Tears (AT) (OTHER).
Who is sponsoring clinical trial NCT07588152?
This trial is sponsored by Indiana University, which has 890 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07588152's enrollment target sits among peer trials
50 1255th of 2000 higher than 678 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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