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NCT07587268 · ClinicalTrials.gov registry record
Molecular Profiling for Risk Stratification in Appendiceal Cancer
A clinical trial, sponsored by City of Hope Medical Center.
- Recruiting
- Registry status
- 400
- Enrollment target
NCT07587268: Recruiting study, sponsored by City of Hope Medical Center.
NCT07587268 is a clinical trial that is actively recruiting participants, run by City of Hope Medical Center. The registered enrollment target is 400 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07587268 is actively recruiting participants, sponsored by City of Hope Medical Center.
- RECRUITING
- Registry status
- 400 participants
- Enrollment target
Study Summary
This study investigates integrated epigenetic and epitranscriptomic features of appendiceal cancer using archived tumor tissue specimens from the same patient cohort. The study includes DNA methylation profiling and m6A epitranscriptomic profiling to define molecular subtypes, evaluate associations with clinicopathologic features, and develop molecular risk scores for prognostic stratification. The primary goal is to determine whether DNA methylation- and m6A-based molecular features can complement conventional histopathologic grading and improve risk stratification.
Primary Outcome
Overall survival will be evaluated in relation to molecular profiling results and available clinicopathologic characteristics. Survival analyses may include Kaplan-Meier analysis and Cox proportional hazards models
Interventions
- DIAGNOSTIC_TEST DNA Methylation Profiling
- DIAGNOSTIC_TEST m6A Epitranscriptomic Profiling
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 400 participants |
| Start Date | 2026-05-01 |
| Est. Completion | 2027-01-01 |
What NCT07587268 shows while recruiting
NCT07587268 is an observational study that tracks outcomes without assigning an intervention. The registered 400 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 2 interventions - of which DNA Methylation Profiling is the first listed.
NCT07587268 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07587268 about?
NCT07587268 is a clinical study titled "Molecular Profiling for Risk Stratification in Appendiceal Cancer". This study investigates integrated epigenetic and epitranscriptomic features of appendiceal cancer using archived tumor tissue specimens from the same patient cohort. The study includes DNA methylation profiling and m6A epitranscriptomic profiling to define molecular subtypes, evaluate associations ...
What is the current status of trial NCT07587268?
This trial is currently recruiting. The enrollment target is 400 participants. The study started on 2026-05-01. Estimated completion is 2027-01-01.
What interventions are being tested in trial NCT07587268?
The interventions under investigation include: DNA Methylation Profiling (DIAGNOSTIC_TEST), m6A Epitranscriptomic Profiling (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT07587268?
This trial is sponsored by City of Hope Medical Center, which has 582 total clinical trials registered on ClinicalTrials.gov.
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