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NCT07580183 · ClinicalTrials.gov registry record · NA
Spatial Scene Recognition Memory in Epilepsy Surgery
A NA study, sponsored by University of California, Davis.
- Recruiting
- Registry status
- NA
- Development phase
- 620
- Enrollment target
NCT07580183: Recruiting NA study, sponsored by University of California, Davis.
NCT07580183 is a NA study that is actively recruiting participants, run by University of California, Davis. The registered enrollment target is 620 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (56% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07580183, a NA study, is actively recruiting participants, sponsored by University of California, Davis.
- RECRUITING
- Registry status
- NA
- Development phase
- 620 participants
- Enrollment target
Study Summary
This study investigates the anatomical and physiological basis of spatial scene recognition memory in patients with temporal lobe epilepsy and temporal lobe lesions. Standard neuropsychological tests are insensitive to important memory deficits experienced by patients, particularly in spatial/scene memory, recollective experience, and familiarity processing. Using a validated virtual tour paradigm, the study examines how familiarity-based recognition and recall of spatial scenes relate to specific brain structures. In Aim I, a large cohort of patients with varied temporal lobe lesions at Emory University undergoes the virtual tour task with voxel-based lesion-symptom mapping to localize necessary brain regions. In Aim II, scalp event-related potentials and eye tracking in healthy participants at UC Davis characterize the temporal dynamics and lateralization of scene recognition. In Aim III, intracranial EEG recordings (including local field potentials and single-unit activity) in epilepsy surgery patients at UC Davis determine the precise network dynamics underlying spatial scene familiarity and recall. The long-term goal is to improve the prediction and prevention of cognitive morbidity from epilepsy surgery by providing a more complete model of spatial recognition memory circuits.
Primary Outcome
Rate of correct familiarity judgments for spatially similar test scenes versus novel scenes (recognition without identification/RWI effect), measured as the proportion of "familiar" responses to configurally matched scenes minus false alarm rate to novel scenes.
Interventions
- BEHAVIORAL Virtual Tour Recognition Memory Task
- DEVICE Intracranial EEG Recording with Research Electrodes (Aim III only)
- DIAGNOSTIC_TEST MRI Neuroimaging and Neuropsychological Assessment (Aim I)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 620 participants |
| Start Date | 2024-07-01 |
| Est. Completion | 2030-06-30 |
| Phase | NA |
What NCT07580183 shows while recruiting
NCT07580183 is an interventional study that assigns participants to a tested intervention. The registered 620 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (56% lower).
The record links to 0 conditions, and to 3 interventions - of which Virtual Tour Recognition Memory Task is the first listed.
NCT07580183 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07580183 about?
NCT07580183 is a clinical study titled "Spatial Scene Recognition Memory in Epilepsy Surgery". This study investigates the anatomical and physiological basis of spatial scene recognition memory in patients with temporal lobe epilepsy and temporal lobe lesions. Standard neuropsychological tests are insensitive to important memory deficits experienced by patients, particularly in spatial/scene ...
What is the current status of trial NCT07580183?
This trial is currently recruiting. It is a NA study. The enrollment target is 620 participants. The study started on 2024-07-01. Estimated completion is 2030-06-30.
What interventions are being tested in trial NCT07580183?
The interventions under investigation include: Virtual Tour Recognition Memory Task (BEHAVIORAL), Intracranial EEG Recording with Research Electrodes (Aim III only) (DEVICE), MRI Neuroimaging and Neuropsychological Assessment (Aim I) (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT07580183?
This trial is sponsored by University of California, Davis, which has 657 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07580183's enrollment target sits among peer trials
620 161st of 2000 higher than 1,840 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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