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NCT07550517 · ClinicalTrials.gov registry record · Phase 2
PSMA-High: EBRT/ PSMA617/ ADT vs. EBRT/ ADT
A Phase 2 study, sponsored by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.
- Not yet
- Registry status
- Phase 2
- Development phase
- 60
- Enrollment target
NCT07550517: Clinical Trial Phase 2 study, sponsored by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.
NCT07550517 is a Phase 2 study that has not yet begun recruiting, run by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. The registered enrollment target is 60 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (55% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07550517, a Phase 2 study, has not yet begun recruiting, sponsored by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.
- NOT YET RECRUITING
- Registry status
- Phase 2
- Development phase
- 60 participants
- Enrollment target
Study Summary
This research is being done to find out if the study drug, 177Lu-PSMA-617, given before and during standard of care External Beam Radiation Therapy (EBRT) treatment, with a shorter course of Androgen Deprivation Therapy (ADT) (6 months) is (1) safe and effective compared to standard of care alone, and (2) can reduce the side effects caused by long-term (24 months) ADT in men with high risk localized prostate cancer.
Primary Outcome
The rate of testosterone recovery (TR) will be determined by the percentage of patients who recover normal T levels within 3 years after randomization.
Interventions
- DRUG EBRT + 6 mo ADT + 177Lu-PSMA-617
- RADIATION EBRT + 24 mo ADT
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2026-07 |
| Est. Completion | 2033-07 |
| Phase | Phase 2 |
What is known before NCT07550517 opens enrollment
NCT07550517 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (55% lower).
The record links to 0 conditions, and to 2 interventions - of which EBRT + 6 mo ADT + 177Lu-PSMA-617 is the first listed.
NCT07550517 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07550517 about?
NCT07550517 is a clinical study titled "PSMA-High: EBRT/ PSMA617/ ADT vs. EBRT/ ADT". This research is being done to find out if the study drug, 177Lu-PSMA-617, given before and during standard of care External Beam Radiation Therapy (EBRT) treatment, with a shorter course of Androgen Deprivation Therapy (ADT) (6 months) is (1) safe and effective compared to standard of care alone, a...
What is the current status of trial NCT07550517?
This trial is currently not yet recruiting. It is a Phase 2 study. The enrollment target is 60 participants. The study started on 2026-07. Estimated completion is 2033-07.
What interventions are being tested in trial NCT07550517?
The interventions under investigation include: EBRT + 6 mo ADT + 177Lu-PSMA-617 (DRUG), EBRT + 24 mo ADT (RADIATION).
Who is sponsoring clinical trial NCT07550517?
This trial is sponsored by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, which has 523 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07550517's enrollment target sits among peer trials
60 1027th of 2000 higher than 868 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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