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NCT07529717 · ClinicalTrials.gov registry record · Phase 1
First-in-Human Study to Evaluate AZD8359 STEAP2 TCE in Participants With Prostate Cancer
A Phase 1 study, sponsored by AstraZeneca.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 42
- Enrollment target
NCT07529717: Recruiting Phase 1 study, sponsored by AstraZeneca.
NCT07529717 is a Phase 1 study that is actively recruiting participants, run by AstraZeneca. The registered enrollment target is 42 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (30% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07529717, a Phase 1 study, is actively recruiting participants, sponsored by AstraZeneca.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 42 participants
- Enrollment target
Study Summary
This study is being conducted to learn more about the safety, tolerability, and effectiveness of an experimental treatment for metastatic prostate cancer called AZD8359. The study is split into different modules which will look at AZD8359 delivered by different methods. The study is also further split into 2 parts, Part A which will test different dose levels and dosing schedules of AZD8359 to determine which doses are the best in terms of safety and side effects (dose escalation), and Part B will further test at least two AZD8359 doses in a larger group of participants (dose expansion).
Primary Outcome
Number of participants with AEs, AESIs, SAEs, including AEs leading to discontinuation of study intervention and clinically significant alterations from baseline in laboratory parameters, vital signs, ECGs and physical examination results
Interventions
- DRUG AZD8359
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 42 participants |
| Start Date | 2026-05-18 |
| Est. Completion | 2027-11-17 |
| Phase | Phase 1 |
What NCT07529717 shows while recruiting
NCT07529717 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 42 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (30% lower).
The record links to 0 conditions, and to 1 intervention - of which AZD8359 is the first listed.
NCT07529717 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07529717 about?
NCT07529717 is a clinical study titled "First-in-Human Study to Evaluate AZD8359 STEAP2 TCE in Participants With Prostate Cancer". This study is being conducted to learn more about the safety, tolerability, and effectiveness of an experimental treatment for metastatic prostate cancer called AZD8359. The study is split into different modules which will look at AZD8359 delivered by different methods. The study is also further spl...
What is the current status of trial NCT07529717?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 42 participants. The study started on 2026-05-18. Estimated completion is 2027-11-17.
What interventions are being tested in trial NCT07529717?
The interventions under investigation include: AZD8359 (DRUG).
Who is sponsoring clinical trial NCT07529717?
This trial is sponsored by AstraZeneca, which has 1,285 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07529717's enrollment target sits among peer trials
42 1105th of 2000 higher than 876 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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