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NCT07527273 · ClinicalTrials.gov registry record · NA
Cognitive Enhancement in Recurrent Depression (The COG-D-R Study)
A NA study, sponsored by Vanderbilt University Medical Center.
- Not yet
- Registry status
- NA
- Development phase
- 69
- Enrollment target
NCT07527273: Clinical Trial NA study, sponsored by Vanderbilt University Medical Center.
NCT07527273 is a NA study that has not yet begun recruiting, run by Vanderbilt University Medical Center. The registered enrollment target is 69 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07527273, a NA study, has not yet begun recruiting, sponsored by Vanderbilt University Medical Center.
- NOT YET RECRUITING
- Registry status
- NA
- Development phase
- 69 participants
- Enrollment target
Study Summary
The goal of this clinical trial is to learn if a combination of non-drug treatments works to benefit memory, thinking, and brain functioning in older individuals with recurrent depression. The non-drug approaches the investigators are studying include transcranial direct current stimulation (tDCS) and computerized cognitive training. tDCS uses small currents of electricity on the forehead to potentially stimulate your brain's ability to process and learn. Computerized cognitive training uses tablet games to improve memory and thinking. In this study, two different cognitive training programs are being investigated, both of which are stimulating and designed to engage brain activity. One that is believed to be a specific treatment for depression, while the other provides extra stimulation for the brain that is non-specific. Two different tDCS parameters - active stimulation and sham (or placebo) stimulation - are also being investigated. Participants will be randomized to one of three study groups: 1. Depression cognitive training treatment with active brain stimulation 2. Depression cognitive training treatment with sham brain stimulation 3. Non-specific cognitive training treatment with sham brain stimulation The main questions this clinical trial aims to answer are: * Does "depression cognitive training treatment with active brain stimulation" benefit thinking and memory more so than the other treatments? * Does "depression cognitive training treatment with active brain stimulation" benefit brain functioning more so than the other treatments? Participants will: * Complete several baseline and post-intervention visits at the research center for checkups and tests over the course of 3-4 months. * Visit the research center daily for 4 weeks to complete their assigned treatment.
Primary Outcome
This objective cognitive test battery assesses a range of executive functions (working memory, inhibition, set shifting, fluency, and planning). The investigators will examine intervention-related change its Executive Composite Score (primary outcome), and subcomposite (Cognitive Control, Working Memory, and Fluency; secondary outcomes) scores, where higher scores indicate better performance.
Interventions
- DEVICE tDCS (active stimulation)
- DEVICE tDCS (sham stimulation)
- BEHAVIORAL Depression Cognitive Training
- BEHAVIORAL Non-Specific Cognitive Training
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 69 participants |
| Start Date | 2026-09-01 |
| Est. Completion | 2028-06-30 |
| Phase | NA |
What is known before NCT07527273 opens enrollment
NCT07527273 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 69 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower).
The record links to 0 conditions, and to 4 interventions - of which tDCS (active stimulation) is the first listed.
NCT07527273 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07527273 about?
NCT07527273 is a clinical study titled "Cognitive Enhancement in Recurrent Depression (The COG-D-R Study)". The goal of this clinical trial is to learn if a combination of non-drug treatments works to benefit memory, thinking, and brain functioning in older individuals with recurrent depression. The non-drug approaches the investigators are studying include transcranial direct current stimulation (tDCS) a...
What is the current status of trial NCT07527273?
This trial is currently not yet recruiting. It is a NA study. The enrollment target is 69 participants. The study started on 2026-09-01. Estimated completion is 2028-06-30.
What interventions are being tested in trial NCT07527273?
The interventions under investigation include: tDCS (active stimulation) (DEVICE), tDCS (sham stimulation) (DEVICE), Depression Cognitive Training (BEHAVIORAL), Non-Specific Cognitive Training (BEHAVIORAL).
Who is sponsoring clinical trial NCT07527273?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07527273's enrollment target sits among peer trials
69 1133rd of 2000 higher than 868 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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