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NCT07511361 · ClinicalTrials.gov registry record · Phase 2
Study of Efficacy and Safety of Tonlamarsen in Participants With a Recent Hospitalization and a Concurrent Episode of Acute Severe Hypertension
A Phase 2 study, sponsored by Kardigan.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 140
- Enrollment target
NCT07511361: Recruiting Phase 2 study, sponsored by Kardigan.
NCT07511361 is a Phase 2 study that is actively recruiting participants, run by Kardigan. The registered enrollment target is 140 participants, roughly in line with the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07511361, a Phase 2 study, is actively recruiting participants, sponsored by Kardigan.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 140 participants
- Enrollment target
Study Summary
The purpose of this study is to evaluate the blood pressure-lowering effect of tonlamarsen in adult participants who were recently hospitalized and concurrently experienced an episode of acute severe hypertension.
Primary Outcome
* Change from baseline in plasma angiotensinogen (AGT) levels and systolic blood pressure * Variability in plasma AGT levels and systolic blood pressure
Interventions
- DRUG Placebo
- DRUG Tonlamarsen
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 140 participants |
| Start Date | 2026-06-23 |
| Est. Completion | 2027-02 |
| Phase | Phase 2 |
What NCT07511361 shows while recruiting
NCT07511361 is an interventional study that assigns participants to a tested intervention. The registered 140 participants enrollment target is mid-sized for trials with a published cap, roughly in line with the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target.
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT07511361 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07511361 about?
NCT07511361 is a clinical study titled "Study of Efficacy and Safety of Tonlamarsen in Participants With a Recent Hospitalization and a Concurrent Episode of Acute Severe Hypertension". The purpose of this study is to evaluate the blood pressure-lowering effect of tonlamarsen in adult participants who were recently hospitalized and concurrently experienced an episode of acute severe hypertension.
What is the current status of trial NCT07511361?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 140 participants. The study started on 2026-06-23. Estimated completion is 2027-02.
What interventions are being tested in trial NCT07511361?
The interventions under investigation include: Placebo (DRUG), Tonlamarsen (DRUG).
Who is sponsoring clinical trial NCT07511361?
This trial is sponsored by Kardigan, which has 4 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07511361's enrollment target sits among peer trials
140 512th of 2000 higher than 1,476 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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