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NCT07508722 · ClinicalTrials.gov registry record · NA
Transcranial Ultrasonic Neuromodulation of Primary Visual Cortex and Primary Auditory Cortex in Humans
A NA study, sponsored by Massachusetts Institute of Technology.
- Not yet
- Registry status
- NA
- Development phase
- 20
- Enrollment target
NCT07508722 is a NA study that has not yet begun recruiting, run by Massachusetts Institute of Technology. The registered enrollment target is 20 participants.
The verdict
NCT07508722, a NA study, has not yet begun recruiting, sponsored by Massachusetts Institute of Technology.
- NOT YET RECRUITING
- Registry status
- NA
- Development phase
- 20 participants
- Enrollment target
Study Summary
There are a number of disorders of the brain that have limited treatment options, such as chronic pain, addiction, and major depression. A new technology has emerged in the last decade known as transcranial focused ultrasound, which can deliver focused acoustic signals through the skull to modulate brain activity over a small region, including structures deep in the brain. This has resulted in many ongoing clinical trials for various disorders, but there is still a lack of understanding of the optimal sonication parameters for increasing versus decreasing brain activity. The investigators aim to address this open question by sonicating the primary visual cortex and primary auditory cortex in human with a range of sonication parameters. These brain structures were chosen to target because they are expected to elicit perceptual responses in the subject (i.e., the subject will report visual and auditory perception during sonication), allowing the experimenters to infer directly the extent to which neural signals can propagate through the visual and auditory systems in a way that is sufficient to produce conscious perception. Such findings have applications not only in clinical treatments, but also in the fundamental science of the neural basis of sensory perception. Previous work has shown that sonicating the visual cortex in humans can elicit visual perception, but the ultrasonic system in prior work did not have the focusing capabilities that will be employed in this study. At the end of this study, the investigators will have determined the optimal sonication parameters that can elicit neural responses over a small volume over sensory cortex, which can be inferred from visual percepts being localized in space (e.g., a bright spot as opposed to a diffuse light), and auditory percepts that sound like pure tones rather than a broad set of frequencies (e.g., sounding like white noise or static).
Interventions
- DEVICE Magnetic Resonance Imaging
- DEVICE Transcranial Focused Ultrasound Stimulation
- DEVICE Electroencephalography
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2026-10-01 |
| Est. Completion | 2027-06-01 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07508722
The ClinicalTrials.gov registry entry for NCT07508722 describes a study currently listed as not yet recruiting, categorized as NA. The registered enrollment target is 20 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Massachusetts Institute of Technology, which has 24 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 3 interventions - of which Magnetic Resonance Imaging is the first listed.
NCT07508722 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT07508722 about?
NCT07508722 is a clinical study titled "Transcranial Ultrasonic Neuromodulation of Primary Visual Cortex and Primary Auditory Cortex in Humans". There are a number of disorders of the brain that have limited treatment options, such as chronic pain, addiction, and major depression. A new technology has emerged in the last decade known as transcranial focused ultrasound, which can deliver focused acoustic signals through the skull to modulate ...
What is the current status of trial NCT07508722?
This trial is currently not yet recruiting. It is a NA study. The enrollment target is 20 participants. The study started on 2026-10-01. Estimated completion is 2027-06-01.
What interventions are being tested in trial NCT07508722?
The interventions under investigation include: Magnetic Resonance Imaging (DEVICE), Transcranial Focused Ultrasound Stimulation (DEVICE), Electroencephalography (DEVICE).
Who is sponsoring clinical trial NCT07508722?
This trial is sponsored by Massachusetts Institute of Technology, which has 24 total clinical trials registered on ClinicalTrials.gov.
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