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NCT07506993 · ClinicalTrials.gov registry record
Inflammation in Clear Aligners With and Without Attachments
A clinical trial, sponsored by University of Nebraska.
- Recruiting
- Registry status
- 30
- Enrollment target
NCT07506993: Recruiting study, sponsored by University of Nebraska.
NCT07506993 is a clinical trial that is actively recruiting participants, run by University of Nebraska. The registered enrollment target is 30 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07506993 is actively recruiting participants, sponsored by University of Nebraska.
- RECRUITING
- Registry status
- 30 participants
- Enrollment target
Study Summary
Problem: Clear aligner therapy is widely used in orthodontics due to improved periodontal outcomes compared to fixed appliances. However, composite attachments are frequently bonded to molars to enhance biomechanics, potentially creating plaque-retentive areas that may increase localized inflammatory responses. Currently, no studies have directly compared periodontal inflammatory biomarker levels in molars treated with clear aligners with versus without attachments. This gap limits understanding of the biological impact of attachments on periodontal tissues.Hypothesis:First molars treated with clear aligners and composite attachments will demonstrate higher levels of inflammatory biomarkers in gingival crevicular fluid (GCF) compared to molars treated with clear aligners without attachments. Biomarker levels are expected to be lower in the non-attachment group. Methods: This study will include 30 orthodontic patients divided into two groups (15 per group):1. Clear aligners with molar attachments 2. Clear aligners without molar attachments. GCF samples will be collected from first molars at a routine orthodontic appointment at the UNMC College of Dentistry Graduate Orthodontic Clinic. Primary biomarkers include IL-1β, IL-6, TNF-α, and MMP-8 measured via ELISA. Clinical periodontal parameters (Plaque Index, Gingival Index, Bleeding on Probing, Probing Depth) will also be recorded.
Primary Outcome
Measure of IL-1B at molar sites
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2026-05-01 |
| Est. Completion | 2027-05-01 |
What NCT07506993 shows while recruiting
NCT07506993 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 30 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT07506993 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07506993 about?
NCT07506993 is a clinical study titled "Inflammation in Clear Aligners With and Without Attachments". Problem: Clear aligner therapy is widely used in orthodontics due to improved periodontal outcomes compared to fixed appliances. However, composite attachments are frequently bonded to molars to enhance biomechanics, potentially creating plaque-retentive areas that may increase localized inflammator...
What is the current status of trial NCT07506993?
This trial is currently recruiting. The enrollment target is 30 participants. The study started on 2026-05-01. Estimated completion is 2027-05-01.
Who is sponsoring clinical trial NCT07506993?
This trial is sponsored by University of Nebraska, which has 407 total clinical trials registered on ClinicalTrials.gov.
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