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NCT07506681 · ClinicalTrials.gov registry record · NA
IMAT Quality in Aging
A NA study, sponsored by Washington University School of Medicine.
- Not yet
- Registry status
- NA
- Development phase
- 16
- Enrollment target
NCT07506681: Clinical Trial NA study, sponsored by Washington University School of Medicine.
NCT07506681 is a NA study that has not yet begun recruiting, run by Washington University School of Medicine. The registered enrollment target is 16 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07506681, a NA study, has not yet begun recruiting, sponsored by Washington University School of Medicine.
- NOT YET RECRUITING
- Registry status
- NA
- Development phase
- 16 participants
- Enrollment target
Study Summary
This study will test the central hypothesis that fat within the muscle, or intramuscular adipose tissue (IMAT), exhibits elevated damage and pro-inflammatory signaling with aging, both of which are reduced by progressive resistance exercise (PRE). Sixteen older adults 65-80 years old will be recruited and complete a 12 week calf PRE intervention. Calf muscle strength, composition (measured by computed tomography) and muscle biopsies will be collected before and after the intervention. Histology, transcriptomic and secretomic tests will be completed to assess signs of damage and inflammation.
Primary Outcome
Senescent cells will be identified by expression of β-galactosidase (b-gal) and p16 on histological sections from muscle biopsies. B-gal and p16 positive cells will be counted and normalized to the histological region of interest to obtain a measure of density (# senescent cells / mm\^2).
Interventions
- OTHER Calf muscle strengthening
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 16 participants |
| Start Date | 2026-04-15 |
| Est. Completion | 2028-01 |
| Phase | NA |
What is known before NCT07506681 opens enrollment
NCT07506681 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 16 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 1 intervention - of which Calf muscle strengthening is the first listed.
NCT07506681 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07506681 about?
NCT07506681 is a clinical study titled "IMAT Quality in Aging". This study will test the central hypothesis that fat within the muscle, or intramuscular adipose tissue (IMAT), exhibits elevated damage and pro-inflammatory signaling with aging, both of which are reduced by progressive resistance exercise (PRE). Sixteen older adults 65-80 years old will be recruit...
What is the current status of trial NCT07506681?
This trial is currently not yet recruiting. It is a NA study. The enrollment target is 16 participants. The study started on 2026-04-15. Estimated completion is 2028-01.
What interventions are being tested in trial NCT07506681?
The interventions under investigation include: Calf muscle strengthening (OTHER).
Who is sponsoring clinical trial NCT07506681?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07506681's enrollment target sits among peer trials
16 1871st of 2000 higher than 120 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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