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NCT07503002 · ClinicalTrials.gov registry record · Phase 1

Shortened LSD Intervention for Major Depressive Disorder

A Phase 1 study, sponsored by Johns Hopkins University.

Not yet
Registry status
Phase 1
Development phase
10
Enrollment target

NCT07503002: Clinical Trial Phase 1 study, sponsored by Johns Hopkins University.

NCT07503002 is a Phase 1 study that has not yet begun recruiting, run by Johns Hopkins University. The registered enrollment target is 10 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (83% lower). According to ClinicalTrials.gov, the official US trial registry.

View on ClinicalTrials.gov ↗

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The verdict

NCT07503002, a Phase 1 study, has not yet begun recruiting, sponsored by Johns Hopkins University.

NOT YET RECRUITING
Registry status
Phase 1
Development phase
10 participants
Enrollment target

Study Summary

The purpose of this study is to determine the safety and clinical effectiveness of a shortened lysergic acid diethylamide (LSD) experience. This will be achieved by administering the drug risperidone 45-minutes after the administration of LSD.

Primary Outcome

Score range from 0 to 60. Higher scores indicate worse depression symptoms

Interventions

  • DRUG LSD
  • DRUG Risperidone

Trial Details

FieldValue
Enrollment Target 10 participants
Start Date 2026-07-01
Est. Completion 2027-12-01
Phase Phase 1
Johns Hopkins University

1,448 total trials

What is known before NCT07503002 opens enrollment

NCT07503002 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (83% lower).

The record links to 0 conditions, and to 2 interventions - of which LSD is the first listed.

NCT07503002 does not publish any study locations in the registry export this page uses.

Frequently Asked Questions

What is clinical trial NCT07503002 about?

NCT07503002 is a clinical study titled "Shortened LSD Intervention for Major Depressive Disorder". The purpose of this study is to determine the safety and clinical effectiveness of a shortened lysergic acid diethylamide (LSD) experience. This will be achieved by administering the drug risperidone 45-minutes after the administration of LSD.

What is the current status of trial NCT07503002?

This trial is currently not yet recruiting. It is a Phase 1 study. The enrollment target is 10 participants. The study started on 2026-07-01. Estimated completion is 2027-12-01.

What interventions are being tested in trial NCT07503002?

The interventions under investigation include: LSD (DRUG), Risperidone (DRUG).

Who is sponsoring clinical trial NCT07503002?

This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.

How this trial's enrollment target compares

Where NCT07503002's enrollment target sits among peer trials

10 1913th of 2000 higher than 46 of 2,000 other Phase 1 trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Source: ClinicalTrials.gov NCT07503002, the US trial registry maintained by the National Library of Medicine. NCT07503002 (small enrollment · none site footprint · not yet recruiting) retrieved and formatted by PlainTrial, see methodology.