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NCT07502872 · ClinicalTrials.gov registry record · Phase 2
TPG: Tafasitamab, Polatuzumab Vedotin, and Glofitamab as First-line Therapy for Diffuse Large B-cell Lymphoma and High-grade B-cell Lymphoma
A Phase 2 study, sponsored by Brown University.
- Not yet
- Registry status
- Phase 2
- Development phase
- 30
- Enrollment target
NCT07502872: Clinical Trial Phase 2 study, sponsored by Brown University.
NCT07502872 is a Phase 2 study that has not yet begun recruiting, run by Brown University. The registered enrollment target is 30 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (77% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07502872, a Phase 2 study, has not yet begun recruiting, sponsored by Brown University.
- NOT YET RECRUITING
- Registry status
- Phase 2
- Development phase
- 30 participants
- Enrollment target
Study Summary
This is a single-center, phase 2, open-label clinical trial of a novel combination of polatuzumab vedotin, glofitamab, and tafasitamab (TPG) as first-line treatment of patients with diffuse large B cell lymphoma (DLBCL) or high-grade B cell lymphoma (HGBL).
Primary Outcome
• Complete response (CR) rate after 4 cycles of TPG therapy, evaluated by PET-CT using Lugano criteria
Interventions
- DRUG Obinutuzumab
- DRUG Glofitamab
- DRUG Polatuzumab vedotin
- DRUG Tafasitamab
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2026-05-01 |
| Est. Completion | 2029-12-01 |
| Phase | Phase 2 |
What is known before NCT07502872 opens enrollment
NCT07502872 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (77% lower).
The record links to 0 conditions, and to 4 interventions - of which Obinutuzumab is the first listed.
NCT07502872 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07502872 about?
NCT07502872 is a clinical study titled "TPG: Tafasitamab, Polatuzumab Vedotin, and Glofitamab as First-line Therapy for Diffuse Large B-cell Lymphoma and High-grade B-cell Lymphoma". This is a single-center, phase 2, open-label clinical trial of a novel combination of polatuzumab vedotin, glofitamab, and tafasitamab (TPG) as first-line treatment of patients with diffuse large B cell lymphoma (DLBCL) or high-grade B cell lymphoma (HGBL).
What is the current status of trial NCT07502872?
This trial is currently not yet recruiting. It is a Phase 2 study. The enrollment target is 30 participants. The study started on 2026-05-01. Estimated completion is 2029-12-01.
What interventions are being tested in trial NCT07502872?
The interventions under investigation include: Obinutuzumab (DRUG), Glofitamab (DRUG), Polatuzumab vedotin (DRUG), Tafasitamab (DRUG).
Who is sponsoring clinical trial NCT07502872?
This trial is sponsored by Brown University, which has 231 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07502872's enrollment target sits among peer trials
30 1582nd of 2000 higher than 332 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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