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NCT07498140 · ClinicalTrials.gov registry record · NA
Procedural Framing and Epidural Steroid Injection Outcomes
A NA study, sponsored by Northwestern University.
- Recruiting
- Registry status
- NA
- Development phase
- 210
- Enrollment target
NCT07498140 is a NA study that is actively recruiting participants, run by Northwestern University. The registered enrollment target is 210 participants.
The verdict
NCT07498140, a NA study, is actively recruiting participants, sponsored by Northwestern University.
- RECRUITING
- Registry status
- NA
- Development phase
- 210 participants
- Enrollment target
Study Summary
Back pain is the leading cause of disability and military medical boards across the globe. Epidural steroid injections (ESI) are the most commonly performed pain procedure in the world. There is strong evidence that the placebo effect for all pain treatments, including ESI, is greater than the intrinsic effect. The placebo effect is highly dependent on a patient's 'expectations', and therefore how the procedure is framed. This study aims to compare ESI when the procedure is framed very positively- as is often done in clinical practice vs. more neutrally (which is less commonly done in clinical practice but consistent with evidence). The placebo effect is also stronger for procedures than medications. The evidence on the benefits of ESI is highly dependent on whether it is compiled by interventional doctors who perform the procedure or non-interventional researchers. In order to determine how 'framing' a treatment affects pain outcomes, the investigative team will conduct a 3-arm randomized trial comparing positive framing of ESI, neutral framing of ESI, and medications, in patients with lumbosacral radiculopathy.
Interventions
- BEHAVIORAL Behavioral manipulation of ESI expectations
- OTHER No behavioral manipulation of ESI expectations
- OTHER No behavioral manipulation of pharmacotherapy expectations
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 210 participants |
| Start Date | 2026-03-30 |
| Est. Completion | 2028-06-30 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07498140
The ClinicalTrials.gov registry entry for NCT07498140 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 210 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Northwestern University, which has 1,209 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 3 interventions - of which Behavioral manipulation of ESI expectations is the first listed.
NCT07498140 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT07498140 about?
NCT07498140 is a clinical study titled "Procedural Framing and Epidural Steroid Injection Outcomes". Back pain is the leading cause of disability and military medical boards across the globe. Epidural steroid injections (ESI) are the most commonly performed pain procedure in the world. There is strong evidence that the placebo effect for all pain treatments, including ESI, is greater than the intr...
What is the current status of trial NCT07498140?
This trial is currently recruiting. It is a NA study. The enrollment target is 210 participants. The study started on 2026-03-30. Estimated completion is 2028-06-30.
What interventions are being tested in trial NCT07498140?
The interventions under investigation include: Behavioral manipulation of ESI expectations (BEHAVIORAL), No behavioral manipulation of ESI expectations (OTHER), No behavioral manipulation of pharmacotherapy expectations (OTHER).
Who is sponsoring clinical trial NCT07498140?
This trial is sponsored by Northwestern University, which has 1,209 total clinical trials registered on ClinicalTrials.gov.
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