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NCT07494084 · ClinicalTrials.gov registry record · Phase 4
Sleep Loss and Circadian Misalignment - Mechanisms of Insulin Resistance
A Phase 4 study, sponsored by Washington State University.
- Not yet
- Registry status
- Phase 4
- Development phase
- 48
- Enrollment target
NCT07494084: Clinical Trial Phase 4 study, sponsored by Washington State University.
NCT07494084 is a Phase 4 study that has not yet begun recruiting, run by Washington State University. The registered enrollment target is 48 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (91% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07494084, a Phase 4 study, has not yet begun recruiting, sponsored by Washington State University.
- NOT YET RECRUITING
- Registry status
- Phase 4
- Development phase
- 48 participants
- Enrollment target
Study Summary
The purpose of this study is to examine the impact of timed cortisol release or differently timed cortisol rhythms on insulin resistance in both men and women undergoing sleep restriction. Chronic sleep loss is highly prevalent, affecting 1 in 3 adults in the US. Chronic sleep loss causes stress which induces insulin resistance and leads to obesity and type 2 diabetes. Many factors contribute to sleep loss including shift work, environmental disturbances, sleep/circadian disorders and comorbid medical and mental health conditions. Sleep loss increases the stress hormone cortisol in the evening and decreases daytime testosterone. Examining these hormones in a controlled laboratory environment under different sleep schedules may help researchers find solutions for adults experiencing negative health consequences related to chronic sleep loss.
Primary Outcome
Insulin resistance-minimal model (Si) will be measured from the frequently sampled intravenous glucose tolerance test (FSIVGTT) and reflects glucose disposal rate during the insulin response. it will be calculated as the change from baseline (by subtraction).
Interventions
- DRUG Dextrose
- DRUG insulin
- DRUG Metyrapone And Hydrocortisone
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2026-07-01 |
| Est. Completion | 2029-07 |
| Phase | Phase 4 |
What is known before NCT07494084 opens enrollment
NCT07494084 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 48 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (91% lower).
The record links to 0 conditions, and to 3 interventions - of which Dextrose is the first listed.
NCT07494084 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07494084 about?
NCT07494084 is a clinical study titled "Sleep Loss and Circadian Misalignment - Mechanisms of Insulin Resistance". The purpose of this study is to examine the impact of timed cortisol release or differently timed cortisol rhythms on insulin resistance in both men and women undergoing sleep restriction. Chronic sleep loss is highly prevalent, affecting 1 in 3 adults in the US. Chronic sleep loss causes stress whi...
What is the current status of trial NCT07494084?
This trial is currently not yet recruiting. It is a Phase 4 study. The enrollment target is 48 participants. The study started on 2026-07-01. Estimated completion is 2029-07.
What interventions are being tested in trial NCT07494084?
The interventions under investigation include: Dextrose (DRUG), insulin (DRUG), Metyrapone And Hydrocortisone (DRUG).
Who is sponsoring clinical trial NCT07494084?
This trial is sponsored by Washington State University, which has 64 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07494084's enrollment target sits among peer trials
48 1331st of 2000 higher than 653 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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