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NCT07470463 · ClinicalTrials.gov registry record
Evaluation of One-Shot Vision Differential Diagnosis (OSVDE) and Multi-Step Conversational Non-Inferiority (MSCNE) in AI Medical Interviewing
A clinical trial of Differential Diagnosis and Diagnostic Accuracy, sponsored by Magic Health Inc. (d.b.a. Nolla Health).
- Recruiting
- Registry status
- 30
- Enrollment target
- 1
- Study location
NCT07470463: Recruiting study of Differential Diagnosis and Diagnostic Accuracy, sponsored by Magic Health Inc. (d.b.a. Nolla Health).
NCT07470463 is a study of Differential Diagnosis and Diagnostic Accuracy that is actively recruiting participants, run by Magic Health Inc. (d.b.a. Nolla Health). The registered enrollment target is 30 participants. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07470463, a study of Differential Diagnosis and Diagnostic Accuracy, is actively recruiting participants, sponsored by Magic Health Inc. (d.b.a. Nolla Health).
- RECRUITING
- Registry status
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
This study evaluates the diagnostic performance of a multimodal artificial intelligence (AI) system (AIMD.1) using de-identified medical images and semi-synthetic patient simulations. The study combines retrospective analysis of existing publicly available image datasets with prospective data collection from board-certified clinicians who complete diagnostic evaluation tasks. In the One-Shot Vision Differential Evaluation (OSVDE) stage, clinicians review individual de-identified medical images and generate a ranked list of potential diagnoses based solely on visual features. In the Multi-Step Conversational Non-Inferiority Evaluation (MSCNE) stage, clinicians complete diagnostic assessments using semi-synthetic patient simulations derived from de-identified medical images. Clinician performance will be compared with the AI system on the same diagnostic tasks. Human participants consist solely of board-certified clinicians who provide diagnostic responses. Medical images and simulated cases are study materials and are not considered study participants. No identifiable patient data are used, and the AI system is evaluated in an offline research environment and is not used for clinical decision-making or patient care.
Primary Outcome
Proportion of evaluated cases in which the primary diagnosis generated by the AI Diagnostic System matches the reference (ground truth) diagnosis. Accuracy will be calculated across de-identified medical image cases and semi-synthetic patient simulation cases and compared with clinician performance.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST AI Diagnostic System (AIMD.1)
Study Locations (1)
New York
- Nolla Health (Magic Health Inc.) - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2026-03-11 |
| Est. Completion | 2026-09-11 |
What NCT07470463 shows while recruiting
NCT07470463 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 30 participants, a relatively small participant target.
The record links to 2 conditions, with Differential Diagnosis appearing as the primary indexed condition, and to 1 intervention - of which AI Diagnostic System (AIMD.1) is the first listed.
NCT07470463 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT07470463 about?
NCT07470463 is a clinical study titled "Evaluation of One-Shot Vision Differential Diagnosis (OSVDE) and Multi-Step Conversational Non-Inferiority (MSCNE) in AI Medical Interviewing". This study evaluates the diagnostic performance of a multimodal artificial intelligence (AI) system (AIMD.1) using de-identified medical images and semi-synthetic patient simulations. The study combines retrospective analysis of existing publicly available image datasets with prospective data collec...
What is the current status of trial NCT07470463?
This trial is currently recruiting. The enrollment target is 30 participants. The study started on 2026-03-11. Estimated completion is 2026-09-11.
What conditions does trial NCT07470463 study?
This clinical trial studies the following conditions: Differential Diagnosis, Diagnostic Accuracy.
What interventions are being tested in trial NCT07470463?
The interventions under investigation include: AI Diagnostic System (AIMD.1) (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT07470463?
This trial is sponsored by Magic Health Inc. (d.b.a. Nolla Health), which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07470463 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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