Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT07459504 · ClinicalTrials.gov registry record · Phase 2
SMART Diets for MASLD
A Phase 2 study, sponsored by Michigan State University.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 102
- Enrollment target
NCT07459504: Recruiting Phase 2 study, sponsored by Michigan State University.
NCT07459504 is a Phase 2 study that is actively recruiting participants, run by Michigan State University. The registered enrollment target is 102 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (23% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07459504, a Phase 2 study, is actively recruiting participants, sponsored by Michigan State University.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 102 participants
- Enrollment target
Study Summary
This phase 2 trial is a single-site sequential, multiple assignment, randomized trial (SMART) to test and construct a high-quality adaptive intervention of essential amino acids (EAA) and/or Low Sugar Diet for children with metabolic dysfunction associated steatotic liver disease (MASLD) and increased cardiometabolic risk. The basis for the trial includes high-quality pilot data in both EAA for hepatic steatosis and a low sugar diet for hepatic steatosis. In the trial, children aged 11-17 years old will be eligible to participate if their BMI is greater than or equal to 95th% at baseline and hepatic steatosis is greater than or equal to 8% at baseline by Magnetic Resonance Imaging Proton Density Fat Fraction (MRI-PDFF) because this is the most common age group diagnosed with metabolic-dysfunction associated steatotic liver disease.
Primary Outcome
Change in hepatic steatosis by magnetic resonance imaging (MRI)
Interventions
- DRUG Essential Amino Acids Supplementation intervention
- OTHER Low sugar diet
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 102 participants |
| Start Date | 2026-06 |
| Est. Completion | 2030-12-26 |
| Phase | Phase 2 |
What NCT07459504 shows while recruiting
NCT07459504 is an interventional study that assigns participants to a tested intervention. The registered 102 participants enrollment target is mid-sized for trials with a published cap, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (23% lower).
The record links to 0 conditions, and to 2 interventions - of which Essential Amino Acids Supplementation intervention is the first listed.
NCT07459504 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07459504 about?
NCT07459504 is a clinical study titled "SMART Diets for MASLD". This phase 2 trial is a single-site sequential, multiple assignment, randomized trial (SMART) to test and construct a high-quality adaptive intervention of essential amino acids (EAA) and/or Low Sugar Diet for children with metabolic dysfunction associated steatotic liver disease (MASLD) and increas...
What is the current status of trial NCT07459504?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 102 participants. The study started on 2026-06. Estimated completion is 2030-12-26.
What interventions are being tested in trial NCT07459504?
The interventions under investigation include: Essential Amino Acids Supplementation intervention (DRUG), Low sugar diet (OTHER).
Who is sponsoring clinical trial NCT07459504?
This trial is sponsored by Michigan State University, which has 120 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07459504's enrollment target sits among peer trials
102 668th of 2000 higher than 1,329 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT03704662 · 102 participants · NA
Preoperative Fractionated Radiation Therapy Versus Stereotactic Body Radiation Therapy for Resectable or Borderline Resectable, or Locally Advanced Type A Pancreatic Adenocarcinoma
- NCT04174742 · 102 participants
Self Reported Pain in Women While Undergoing Treatment for Non-metastatic Breast Cancer
- NCT04275362 · 102 participants
Gait Analysis of a Lateral-Pivot Design Total Knee Replacement
- NCT04541082 · 102 participants · Phase 1
Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia