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RECRUITING Phase 2

A Trial to Evaluate Efficacy and Safety of Maridebart Cafraglutide in Adults Living With Elevated Liver Fat and Obesity or Overweight

NCT07441252 · View on ClinicalTrials.gov ↗

Study Summary

The main objective of this trial will be to determine whether maridebart cafraglutide is superior to placebo on reduction in liver fat content and body weight in participants living with obesity or overweight and elevated liver fat content, when administered in conjunction with reduced-calorie diet and increased physical activity.

Interventions

  • DRUG Placebo
  • DRUG Maridebart cafraglutide

Study Locations (7)

Arizona

  • Arizona Clinical Trials — Chandler
  • Medical Advancement Centers of Arizona — Phoenix

Florida

  • Indago Research and Health Center — Hialeah
  • Floridian Clinical Research LLC — Miami Lakes

Maryland

  • Woodholme Gastroenterology Associates - Glen Burnie — Glen Burnie

Nevada

  • Excel Clinical Research — Las Vegas

Texas

  • McAllen Research — Pharr

Trial Details

FieldValue
Enrollment Target 180 participants
Start Date 2026-03-05
Est. Completion 2027-12-22
Phase Phase 2

Sponsor

Amgen

266 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07441252

The ClinicalTrials.gov registry entry for NCT07441252 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 180 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Amgen, which has 266 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Overweight or Obesity and Elevated Liver Fat appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07441252 reports 7 study locations spanning 5 distinct geographic areas — top geographies include Arizona, Florida, Maryland. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07441252 about?

NCT07441252 is a clinical study titled "A Trial to Evaluate Efficacy and Safety of Maridebart Cafraglutide in Adults Living With Elevated Liver Fat and Obesity or Overweight". The main objective of this trial will be to determine whether maridebart cafraglutide is superior to placebo on reduction in liver fat content and body weight in participants living with obesity or overweight and elevated liver fat content, when administered in conjunction with reduced-calorie diet ...

What is the current status of trial NCT07441252?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 180 participants. The study started on 2026-03-05. Estimated completion is 2027-12-22.

What conditions does trial NCT07441252 study?

This clinical trial studies the following conditions: Overweight or Obesity and Elevated Liver Fat. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07441252?

The interventions under investigation include: Placebo (DRUG), Maridebart cafraglutide (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07441252?

This trial is sponsored by Amgen, which has 266 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07441252 being conducted?

This trial has 7 study locations across Arizona, Florida, Maryland, Nevada, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial