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NCT07438405 · ClinicalTrials.gov registry record · Phase 2
An Open-label, Rollover Trial to Evaluate the Efficacy and Safety of AMG 732 in Participants With Thyroid Eye Disease
A Phase 2 study, sponsored by Amgen.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 30
- Enrollment target
NCT07438405: Recruiting Phase 2 study, sponsored by Amgen.
NCT07438405 is a Phase 2 study that is actively recruiting participants, run by Amgen. The registered enrollment target is 30 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (77% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07438405, a Phase 2 study, is actively recruiting participants, sponsored by Amgen.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 30 participants
- Enrollment target
Study Summary
The main objective of this trial is to assess the efficacy of AMG 732 in participants with thyroid eye disease (TED) who are defined as primary nonresponders or relapsed during the safety follow-up in the parent trial (NCT06401044).
Primary Outcome
Responders are defined as participants with a ≥ 2 mm reduction from baseline in the trial eye without deterioration (≥ 2 mm increase) of proptosis in the fellow eye.
Interventions
- DRUG AMG 732
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2026-05-07 |
| Est. Completion | 2028-07-14 |
| Phase | Phase 2 |
What NCT07438405 shows while recruiting
NCT07438405 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (77% lower).
The record links to 0 conditions, and to 1 intervention - of which AMG 732 is the first listed.
NCT07438405 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07438405 about?
NCT07438405 is a clinical study titled "An Open-label, Rollover Trial to Evaluate the Efficacy and Safety of AMG 732 in Participants With Thyroid Eye Disease". The main objective of this trial is to assess the efficacy of AMG 732 in participants with thyroid eye disease (TED) who are defined as primary nonresponders or relapsed during the safety follow-up in the parent trial (NCT06401044).
What is the current status of trial NCT07438405?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 30 participants. The study started on 2026-05-07. Estimated completion is 2028-07-14.
What interventions are being tested in trial NCT07438405?
The interventions under investigation include: AMG 732 (DRUG).
Who is sponsoring clinical trial NCT07438405?
This trial is sponsored by Amgen, which has 558 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07438405's enrollment target sits among peer trials
30 1582nd of 2000 higher than 332 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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