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NCT07434492 · ClinicalTrials.gov registry record · Phase 2
Smart AFO and 5-Azacitidine to Enhance Mobility in Children With Cerebral Palsy
A Phase 2 study, sponsored by Shirley Ryan AbilityLab.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 60
- Enrollment target
NCT07434492: Recruiting Phase 2 study, sponsored by Shirley Ryan AbilityLab.
NCT07434492 is a Phase 2 study that is actively recruiting participants, run by Shirley Ryan AbilityLab. The registered enrollment target is 60 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (55% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07434492, a Phase 2 study, is actively recruiting participants, sponsored by Shirley Ryan AbilityLab.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 60 participants
- Enrollment target
Study Summary
This is an intervention study to investigate the impact of a smart ankle-foot orthosis (AFO) on mobility outcomes in children with Cerebral Palsy. Participants will complete a three phase protocol including 6-weeks of at home training with the smart AFO. Participants will also have the option to participate in a randomized control trial to investigate the impact of 5-Azacitidine combined with the smart AFO to further effect mobility outcomes.
Primary Outcome
Participants will complete a 6 minute walking test to measure the total distance they can walk in a 6 minute period.
Interventions
- DRUG Placebo
- DRUG 5-Azacitidine
- DEVICE Smart Ankle-Foot Orthosis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2026-05-28 |
| Est. Completion | 2030-08-31 |
| Phase | Phase 2 |
What NCT07434492 shows while recruiting
NCT07434492 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (55% lower).
The record links to 0 conditions, and to 3 interventions - of which Placebo is the first listed.
NCT07434492 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07434492 about?
NCT07434492 is a clinical study titled "Smart AFO and 5-Azacitidine to Enhance Mobility in Children With Cerebral Palsy". This is an intervention study to investigate the impact of a smart ankle-foot orthosis (AFO) on mobility outcomes in children with Cerebral Palsy. Participants will complete a three phase protocol including 6-weeks of at home training with the smart AFO. Participants will also have the option to par...
What is the current status of trial NCT07434492?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 60 participants. The study started on 2026-05-28. Estimated completion is 2030-08-31.
What interventions are being tested in trial NCT07434492?
The interventions under investigation include: Placebo (DRUG), 5-Azacitidine (DRUG), Smart Ankle-Foot Orthosis (DEVICE).
Who is sponsoring clinical trial NCT07434492?
This trial is sponsored by Shirley Ryan AbilityLab, which has 138 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07434492's enrollment target sits among peer trials
60 1027th of 2000 higher than 868 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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