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NCT07430345 · ClinicalTrials.gov registry record · Phase 1
Buprenorphine for Analgesia in Older Adults With Acute Fractures in the Emergency Department
A Phase 1 study, sponsored by The Cooper Health System.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 48
- Enrollment target
NCT07430345: Recruiting Phase 1 study, sponsored by The Cooper Health System.
NCT07430345 is a Phase 1 study that is actively recruiting participants, run by The Cooper Health System. The registered enrollment target is 48 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (20% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07430345, a Phase 1 study, is actively recruiting participants, sponsored by The Cooper Health System.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 48 participants
- Enrollment target
Study Summary
The goal of this clinical trial is to learn if buprenorphine can treat pain in older adults who have broken bones. The main questions it aims to answer are: Is buprenorphine as effective as opioids to treat pain? Are there less side effects with buprenorphine? Researchers will compare buprenorphine and hydromorphone to see if there are differences in pain control and side effects. Participants will be given one of the two study drugs after breaking a bone and asked about their pain scores and side effects for the next 48 hours.
Primary Outcome
Difference in pain scores measured on the numerical rating scale (scale of 0-10, with 10 being maximum pain and 0 being no pain), collected on arrival and measured at one hour and four hours after medication administration
Interventions
- DRUG Buprenorphine 0.15 MG
- DRUG Hydromorphone 0.25 mg IV
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2026-05-07 |
| Est. Completion | 2027-01 |
| Phase | Phase 1 |
What NCT07430345 shows while recruiting
NCT07430345 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 48 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (20% lower).
The record links to 0 conditions, and to 2 interventions - of which Buprenorphine 0.15 MG is the first listed.
NCT07430345 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07430345 about?
NCT07430345 is a clinical study titled "Buprenorphine for Analgesia in Older Adults With Acute Fractures in the Emergency Department". The goal of this clinical trial is to learn if buprenorphine can treat pain in older adults who have broken bones. The main questions it aims to answer are: Is buprenorphine as effective as opioids to treat pain? Are there less side effects with buprenorphine? Researchers will compare buprenorphine...
What is the current status of trial NCT07430345?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 48 participants. The study started on 2026-05-07. Estimated completion is 2027-01.
What interventions are being tested in trial NCT07430345?
The interventions under investigation include: Buprenorphine 0.15 MG (DRUG), Hydromorphone 0.25 mg IV (DRUG).
Who is sponsoring clinical trial NCT07430345?
This trial is sponsored by The Cooper Health System, which has 39 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07430345's enrollment target sits among peer trials
48 1025th of 2000 higher than 948 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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