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NCT07429292 · ClinicalTrials.gov registry record · Phase 4
SPARK Study - Sympathetic Periarterial Radial Block in Healthy Volunteers
A Phase 4 study, sponsored by Duke University.
- Not yet
- Registry status
- Phase 4
- Development phase
- 20
- Enrollment target
NCT07429292: Clinical Trial Phase 4 study, sponsored by Duke University.
NCT07429292 is a Phase 4 study that has not yet begun recruiting, run by Duke University. The registered enrollment target is 20 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07429292, a Phase 4 study, has not yet begun recruiting, sponsored by Duke University.
- NOT YET RECRUITING
- Registry status
- Phase 4
- Development phase
- 20 participants
- Enrollment target
Study Summary
The SPARK Study evaluates changes in peripheral sympathetic vasomotor activity following a targeted, ultrasound-guided periarterial sympathetic block of the distal radial artery in healthy volunteers. Autonomic reactivity will be assessed before and after the block using digit-specific pulse-amplitude index and infrared thermography during standardized cold pressor testing.
Primary Outcome
Pulse Amplitude Index (PAI) is a noninvasive measure of digital perfusion derived from photoplethysmography (PPG) signals recorded from the fingers. PAI reflects changes in pulse waveform amplitude and serves as an indirect marker of peripheral blood flow and sympathetic vasomotor tone. In this study, PAI will be continuously recorded using digital sensors placed on the index and fifth fingers of the hand undergoing periarterial radial block, as well as the contralateral index finger. Measuremen
Interventions
- DRUG Lidocaine 2%
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2026-09 |
| Est. Completion | 2027-04 |
| Phase | Phase 4 |
What is known before NCT07429292 opens enrollment
NCT07429292 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 1 intervention - of which Lidocaine 2% is the first listed.
NCT07429292 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07429292 about?
NCT07429292 is a clinical study titled "SPARK Study - Sympathetic Periarterial Radial Block in Healthy Volunteers". The SPARK Study evaluates changes in peripheral sympathetic vasomotor activity following a targeted, ultrasound-guided periarterial sympathetic block of the distal radial artery in healthy volunteers. Autonomic reactivity will be assessed before and after the block using digit-specific pulse-amplitu...
What is the current status of trial NCT07429292?
This trial is currently not yet recruiting. It is a Phase 4 study. The enrollment target is 20 participants. The study started on 2026-09. Estimated completion is 2027-04.
What interventions are being tested in trial NCT07429292?
The interventions under investigation include: Lidocaine 2% (DRUG).
Who is sponsoring clinical trial NCT07429292?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07429292's enrollment target sits among peer trials
20 1753rd of 2000 higher than 167 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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