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NCT07427121 · ClinicalTrials.gov registry record · NA
Rehab and Mechanical Ventilation
A NA study, sponsored by University of Florida.
- Recruiting
- Registry status
- NA
- Development phase
- 16
- Enrollment target
NCT07427121: Recruiting NA study, sponsored by University of Florida.
NCT07427121 is a NA study that is actively recruiting participants, run by University of Florida. The registered enrollment target is 16 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07427121, a NA study, is actively recruiting participants, sponsored by University of Florida.
- RECRUITING
- Registry status
- NA
- Development phase
- 16 participants
- Enrollment target
Study Summary
The goal of this research study is to evaluate the effects of a single session of rehabilitation in healthy adults, before noninvasive mechanical ventilation (MV). MV can help support breathing function during sleep or illness. High levels of MV support have been reported to alter the function of the diaphragm muscle, the primary breathing muscle, in people with compromised health. However, rehabilitation may have some potential to improve diaphragm function in advance of using MV. This study will test different rehabilitation interventions, including (1) inspiratory strength training (IST), (2) transcutaneous spinal cord stimulation (TSCS), or sham TSCS. Before and after MV, participants will complete breathing strength tests and responses to phrenic nerve stimulation.
Primary Outcome
The most negative pressure generated during a maximal inspiratory effort.
Interventions
- OTHER Sham Stimulation
- DEVICE Spinal cord stimulation
- BEHAVIORAL Inspiratory Strength Training
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 16 participants |
| Start Date | 2026-03-30 |
| Est. Completion | 2027-12-31 |
| Phase | NA |
What NCT07427121 shows while recruiting
NCT07427121 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 16 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 3 interventions - of which Sham Stimulation is the first listed.
NCT07427121 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07427121 about?
NCT07427121 is a clinical study titled "Rehab and Mechanical Ventilation". The goal of this research study is to evaluate the effects of a single session of rehabilitation in healthy adults, before noninvasive mechanical ventilation (MV). MV can help support breathing function during sleep or illness. High levels of MV support have been reported to alter the function of th...
What is the current status of trial NCT07427121?
This trial is currently recruiting. It is a NA study. The enrollment target is 16 participants. The study started on 2026-03-30. Estimated completion is 2027-12-31.
What interventions are being tested in trial NCT07427121?
The interventions under investigation include: Sham Stimulation (OTHER), Spinal cord stimulation (DEVICE), Inspiratory Strength Training (BEHAVIORAL).
Who is sponsoring clinical trial NCT07427121?
This trial is sponsored by University of Florida, which has 1,106 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07427121's enrollment target sits among peer trials
16 1871st of 2000 higher than 120 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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