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NCT07425522 · ClinicalTrials.gov registry record · Phase 1

A Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of RO7823653 in Participants With Diabetic Macular Edema (DME)

A Phase 1 study of Diabetic Macular Edema, sponsored by Genentech.

Recruiting
Registry status
Phase 1
Development phase
93
Enrollment target
3
Study locations

NCT07425522 is a Phase 1 study of Diabetic Macular Edema that is actively recruiting participants, run by Genentech. The registered enrollment target is 93 participants, below the 3,793-participant average among 63 other Diabetic Macular Edema trials with a reported enrollment target (98% lower). The trial reports 3 study locations across 2 states.

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The verdict

NCT07425522, a Phase 1 study of Diabetic Macular Edema, is actively recruiting participants, sponsored by Genentech.

RECRUITING
Registry status
Phase 1
Development phase
93 participants
Enrollment target
3
Study locations

Study Summary

The purpose of this study is to evaluate the safety, tolerability, Pharmacodynamics (PD), and Pharmacokinetics (PK) of multiple doses of RO7823653 in participants with DME, administered by intravitreal (IVT) injection as monotherapy and co-administered with faricimab.

Conditions Studied

Diabetic Macular Edema

Interventions

  • DRUG Faricimab
  • DRUG RO7823653

Study Locations (3)

Texas

  • Retina Research Institute of Texas - Abilene
  • Austin Clinical Research, LLC - Austin

Arizona

  • Associated Retina Consultants - Peoria - DocTrials - PPDS - Peoria

Trial Details

FieldValue
Enrollment Target 93 participants
Start Date 2026-04-01
Est. Completion 2028-11-17
Phase Phase 1

Sponsor

Genentech

332 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07425522

The ClinicalTrials.gov registry entry for NCT07425522 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 93 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 3,793-participant average among 63 other Diabetic Macular Edema trials with a reported enrollment target (98% lower). The listed sponsor is Genentech, which has 332 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Diabetic Macular Edema appearing as the primary indexed condition, and to 2 interventions - of which Faricimab is the first listed.

NCT07425522 reports 3 study locations spanning 2 distinct geographic areas - top geographies include Texas, Arizona.

Frequently Asked Questions

What is clinical trial NCT07425522 about?

NCT07425522 is a clinical study titled "A Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of RO7823653 in Participants With Diabetic Macular Edema (DME)". The purpose of this study is to evaluate the safety, tolerability, Pharmacodynamics (PD), and Pharmacokinetics (PK) of multiple doses of RO7823653 in participants with DME, administered by intravitreal (IVT) injection as monotherapy and co-administered with faricimab.

What is the current status of trial NCT07425522?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 93 participants. The study started on 2026-04-01. Estimated completion is 2028-11-17.

What conditions does trial NCT07425522 study?

This clinical trial studies the following conditions: Diabetic Macular Edema.

What interventions are being tested in trial NCT07425522?

The interventions under investigation include: Faricimab (DRUG), RO7823653 (DRUG).

Who is sponsoring clinical trial NCT07425522?

This trial is sponsored by Genentech, which has 332 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT07425522 being conducted?

This trial has 3 study locations across Arizona, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.