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NCT07393334 · ClinicalTrials.gov registry record · Phase 2
Effects of NLS-133, a Potential Non-Hormonal "On-Demand" Male Contraceptive
A Phase 2 study of Male Contraception and Semen Volume, sponsored by Next Life Sciences.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 10
- Enrollment target
- 1
- Study location
NCT07393334 is a Phase 2 study of Male Contraception and Semen Volume that is actively recruiting participants, run by Next Life Sciences. The registered enrollment target is 10 participants. The trial reports 1 study location across 1 state.
The verdict
NCT07393334, a Phase 2 study of Male Contraception and Semen Volume, is actively recruiting participants, sponsored by Next Life Sciences.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 10 participants
- Enrollment target
- 1
- Study location
Study Summary
NLS-133-CLIN001 is a Phase 2a study designed to assess the safety, tolerability, and effects of NLS-133 (combination of two FDA-approved agents) compared to an active control (FDA-approved pharmacologic agent) or placebo on semen volume and sperm count in 10 in healthy men. Participants will be randomized in a crossover design to receive a single dose of NLS-133, an active control or placebo either 90 or 180 minutes prior to collection of semen. Sperm parameters measured will be count, motility and morphology. A brief questionnaire will be completed by each subject during each treatment cycle that addresses orgasm and ejaculation quality. Safety monitoring will include adverse event reporting, laboratory assessments, and vital signs.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG NLS-133
- DRUG Active Comparator #1
Study Locations (1)
Washington
- Population Center for Research in Human Reproduction and Departments of Medicine, University of Washington - Seattle
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2025-12-02 |
| Est. Completion | 2026-05 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07393334
The ClinicalTrials.gov registry entry for NCT07393334 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 10 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Next Life Sciences, which has 1 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Male Contraception appearing as the primary indexed condition, and to 3 interventions - of which Placebo is the first listed.
NCT07393334 reports 1 study location spanning 1 distinct geographic area - top geographies include Washington.
Frequently Asked Questions
What is clinical trial NCT07393334 about?
NCT07393334 is a clinical study titled "Effects of NLS-133, a Potential Non-Hormonal "On-Demand" Male Contraceptive". NLS-133-CLIN001 is a Phase 2a study designed to assess the safety, tolerability, and effects of NLS-133 (combination of two FDA-approved agents) compared to an active control (FDA-approved pharmacologic agent) or placebo on semen volume and sperm count in 10 in healthy men. Participants will be rand...
What is the current status of trial NCT07393334?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 10 participants. The study started on 2025-12-02. Estimated completion is 2026-05.
What conditions does trial NCT07393334 study?
This clinical trial studies the following conditions: Male Contraception, Semen Volume, Sperm Motility.
What interventions are being tested in trial NCT07393334?
The interventions under investigation include: Placebo (DRUG), NLS-133 (DRUG), Active Comparator #1 (DRUG).
Who is sponsoring clinical trial NCT07393334?
This trial is sponsored by Next Life Sciences, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07393334 being conducted?
This trial has 1 study location across Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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