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NCT07391605 · ClinicalTrials.gov registry record · Phase 2
Descartes-08 in Autoantibody Myositis
A Phase 2 study, sponsored by Cartesian Therapeutics.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 60
- Enrollment target
NCT07391605: Recruiting Phase 2 study, sponsored by Cartesian Therapeutics.
NCT07391605 is a Phase 2 study that is actively recruiting participants, run by Cartesian Therapeutics. The registered enrollment target is 60 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (55% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07391605, a Phase 2 study, is actively recruiting participants, sponsored by Cartesian Therapeutics.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 60 participants
- Enrollment target
Study Summary
This is a randomized, double-blind, placebo-controlled phase 2 study to evaluate the efficacy, safety and tolerability of an autologous T-cells expressing a chimeric antigen receptor (CAR) directed to B-Cell maturation antigen (BCMA) in patients with autoantibody-mediated myositis, including antisynthetase syndrome (ASyS) and dermatomyositis (DM).
Primary Outcome
Proportion of participants in the Descartes-08 group compared with placebo who achieve major improvement marked by ≥60 point improvement on the 2016 ACR/EULAR Total Improvement Score (TIS)
Interventions
- OTHER Placebo
- DRUG Descartes-08
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2026-04-28 |
| Est. Completion | 2028-05 |
| Phase | Phase 2 |
What NCT07391605 shows while recruiting
NCT07391605 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (55% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT07391605 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07391605 about?
NCT07391605 is a clinical study titled "Descartes-08 in Autoantibody Myositis". This is a randomized, double-blind, placebo-controlled phase 2 study to evaluate the efficacy, safety and tolerability of an autologous T-cells expressing a chimeric antigen receptor (CAR) directed to B-Cell maturation antigen (BCMA) in patients with autoantibody-mediated myositis, including antisyn...
What is the current status of trial NCT07391605?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 60 participants. The study started on 2026-04-28. Estimated completion is 2028-05.
What interventions are being tested in trial NCT07391605?
The interventions under investigation include: Placebo (OTHER), Descartes-08 (DRUG).
Who is sponsoring clinical trial NCT07391605?
This trial is sponsored by Cartesian Therapeutics, which has 12 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07391605's enrollment target sits among peer trials
60 1027th of 2000 higher than 868 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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