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NCT07386548 · ClinicalTrials.gov registry record · NA
Biologic Injection For Adults With Lumbar Disc Herniation
A NA study, sponsored by Weill Medical College of Cornell University.
- Not yet
- Registry status
- NA
- Development phase
- 90
- Enrollment target
NCT07386548: Clinical Trial NA study, sponsored by Weill Medical College of Cornell University.
NCT07386548 is a NA study that has not yet begun recruiting, run by Weill Medical College of Cornell University. The registered enrollment target is 90 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (94% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07386548, a NA study, has not yet begun recruiting, sponsored by Weill Medical College of Cornell University.
- NOT YET RECRUITING
- Registry status
- NA
- Development phase
- 90 participants
- Enrollment target
Study Summary
The goal of this clinical trial is to find out whether adding a bone-marrow aspirate concentrate (BMAC) injection during surgery can improve recovery in adults undergoing lumbar microdiscectomy for a lumbar disc herniation. The main questions it aims to answer are: * Does the BMAC injection lead to better disc tissue health after surgery (as seen on MRI scans)? * Does the BMAC injection lead to greater improvement in pain and disability compared to surgery alone? Participants will be adults aged 18 and older who are scheduled for lumbar microdiscectomy surgery. Researchers will compare one group of participants receiving the standard-of-care surgery plus the BMAC injection with another group receiving the same surgery without the injection to see if the injection offers added benefit. Participants will: * Have surgery (microdiscectomy) with or without the injection. * Complete pain and disability questionnaires at several times over 2 years. * Undergo MRI scans at baseline and follow-up to assess disc structure and tissue health. * Provide samples of leftover disc or bone-marrow tissue (as applicable) from surgery for analysis.
Primary Outcome
MRI T2 mapping and T2 relaxation time are advanced imaging techniques that help assess the hydration status of intervertebral discs. These two metrics will be combined as one data point. T2 relaxation time measures the decay of the MRI signal, which is influenced by the water content in the disc. Higher T2 values indicate better hydration, while lower T2 values suggest dehydration and degeneration. T2 mapping provides a detailed, quantitative assessment of the disc's water content, allowing for
Interventions
- OTHER Bone Marrow Aspirate Concentrate (BMAC)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 90 participants |
| Start Date | 2026-05-01 |
| Est. Completion | 2030-12 |
| Phase | NA |
What is known before NCT07386548 opens enrollment
NCT07386548 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 90 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (94% lower).
The record links to 0 conditions, and to 1 intervention - of which Bone Marrow Aspirate Concentrate (BMAC) is the first listed.
NCT07386548 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07386548 about?
NCT07386548 is a clinical study titled "Biologic Injection For Adults With Lumbar Disc Herniation". The goal of this clinical trial is to find out whether adding a bone-marrow aspirate concentrate (BMAC) injection during surgery can improve recovery in adults undergoing lumbar microdiscectomy for a lumbar disc herniation. The main questions it aims to answer are: * Does the BMAC injection lead t...
What is the current status of trial NCT07386548?
This trial is currently not yet recruiting. It is a NA study. The enrollment target is 90 participants. The study started on 2026-05-01. Estimated completion is 2030-12.
What interventions are being tested in trial NCT07386548?
The interventions under investigation include: Bone Marrow Aspirate Concentrate (BMAC) (OTHER).
Who is sponsoring clinical trial NCT07386548?
This trial is sponsored by Weill Medical College of Cornell University, which has 701 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07386548's enrollment target sits among peer trials
90 941st of 2000 higher than 1,029 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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