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AURN001 Efficacy in Participants With Corneal Edema Secondary to Corneal Endothelial Dysfunction
NCT07368959 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to assess the efficacy and safety of single injection dose of AURN001 compared with placebo in adult participants with corneal edema secondary to corneal endothelial dysfunction.
Conditions Studied
Interventions
- OTHER Placebo
- DRUG Combination Product: AURN001 + Y-27632
Study Locations (12)
North Carolina
- Investigational Site 11 — Leland
- Investigational Site 5 — Winston-Salem
Pennsylvania
- Investigational Site 3 — Cynwyd
- Investigational Site 10 — Plymouth Meeting
Texas
- Investigational Site 8 — San Antonio
- Investigational Site 1 — Spring
Arizona
- Investigational Site 2 — Mesa
Arkansas
- Investigational Site 6 — Little Rock
Colorado
- Investigational Site 9 — Fort Collins
Georgia
- Investigational Site 7 — Atlanta
Missouri
- Investigational Site 4 — Kansas City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 120 participants |
| Start Date | 2026-02-19 |
| Est. Completion | 2028-01 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07368959
The ClinicalTrials.gov registry entry for NCT07368959 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 120 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Aurion Biotech, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 4 conditions, with Corneal Edema appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT07368959 reports 12 study locations spanning 9 distinct geographic areas — top geographies include North Carolina, Pennsylvania, Texas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT07368959 about?
NCT07368959 is a clinical study titled "AURN001 Efficacy in Participants With Corneal Edema Secondary to Corneal Endothelial Dysfunction". The purpose of this study is to assess the efficacy and safety of single injection dose of AURN001 compared with placebo in adult participants with corneal edema secondary to corneal endothelial dysfunction.
What is the current status of trial NCT07368959?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 120 participants. The study started on 2026-02-19. Estimated completion is 2028-01.
What conditions does trial NCT07368959 study?
This clinical trial studies the following conditions: Corneal Edema, Corneal Endothelial Dysfunction, Fuchs Endothelial Corneal Dysfunction, Pseudophakic Bullous Keratopathy (PBK). These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT07368959?
The interventions under investigation include: Placebo (OTHER), Combination Product: AURN001 + Y-27632 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT07368959?
This trial is sponsored by Aurion Biotech, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT07368959 being conducted?
This trial has 12 study locations across Arizona, Arkansas, Colorado, Georgia, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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