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NCT07324772 · ClinicalTrials.gov registry record · NA
PREACTIVE: Preconditioning Exercise Intervention to Improve Symptoms and Quality of Life in Comorbid Atrial Fibrillation and HFpEF
A NA study, sponsored by Northwestern University.
- Not yet
- Registry status
- NA
- Development phase
- 30
- Enrollment target
NCT07324772: Clinical Trial NA study, sponsored by Northwestern University.
NCT07324772 is a NA study that has not yet begun recruiting, run by Northwestern University. The registered enrollment target is 30 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07324772, a NA study, has not yet begun recruiting, sponsored by Northwestern University.
- NOT YET RECRUITING
- Registry status
- NA
- Development phase
- 30 participants
- Enrollment target
Study Summary
Atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF) are very common conditions that often occur together and result in worsening symptoms and reduced quality of life (QoL). Limitations being able to participate in activities of daily living is a primary complaint for AF-HFpEF patients, yet effective strategies to address this issue remain limited. While exercise interventions targeting aerobic training (AT) are recommended for patients with AF and HFpEF, unique challenges exist in this patient population who tend to be older. Specifically, many older patients with AF and HFpEF have muscle weakness, sarcopenia and frailty, that can make aerobic-focused exercise difficult and less tolerable. This study proposes that starting with progressive resistance training (PRT) before aerobic exercise may overcome these issues by improving muscle strength, making AT more manageable, and leading to better health outcomes. The goal of this study is to assess whether a sequential exercise program, named 'PREACTIVE' improves how people feel, decrease the amount of symptoms, and their ability to participate in exercise and activities. This study will specifically test a sequenced exercise approach of resistance training followed by aerobic exercise to improve symptoms, and quality of life in AF-HFpEF.
Primary Outcome
Submaximal aerobic capacity by the 6-minute walk test \[6MWT\]
Interventions
- BEHAVIORAL progressive resistance training
- BEHAVIORAL combined aerobic + resistance training
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2026-04-13 |
| Est. Completion | 2027-05 |
| Phase | NA |
What is known before NCT07324772 opens enrollment
NCT07324772 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 2 interventions - of which progressive resistance training is the first listed.
NCT07324772 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07324772 about?
NCT07324772 is a clinical study titled "PREACTIVE: Preconditioning Exercise Intervention to Improve Symptoms and Quality of Life in Comorbid Atrial Fibrillation and HFpEF". Atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF) are very common conditions that often occur together and result in worsening symptoms and reduced quality of life (QoL). Limitations being able to participate in activities of daily living is a primary complaint for ...
What is the current status of trial NCT07324772?
This trial is currently not yet recruiting. It is a NA study. The enrollment target is 30 participants. The study started on 2026-04-13. Estimated completion is 2027-05.
What interventions are being tested in trial NCT07324772?
The interventions under investigation include: progressive resistance training (BEHAVIORAL), combined aerobic + resistance training (BEHAVIORAL).
Who is sponsoring clinical trial NCT07324772?
This trial is sponsored by Northwestern University, which has 1,209 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07324772's enrollment target sits among peer trials
30 1593rd of 2000 higher than 299 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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