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NCT07322133 · ClinicalTrials.gov registry record · Phase 4
Dopamine vs. Norepinephrine for Hypotension in Neonates With Pulmonary Hypertension (DONE)
A Phase 4 study of Hypotension and Shock and Hypoxemic Respiratory Failure, sponsored by University of California, Davis.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 30
- Enrollment target
- 1
- Study location
NCT07322133 is a Phase 4 study of Hypotension and Shock and Hypoxemic Respiratory Failure that is actively recruiting participants, run by University of California, Davis. The registered enrollment target is 30 participants. The trial reports 1 study location across 1 state.
The verdict
NCT07322133, a Phase 4 study of Hypotension and Shock and Hypoxemic Respiratory Failure, is actively recruiting participants, sponsored by University of California, Davis.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
This pilot randomized clinical trial compares dopamine and norepinephrine as first-line vasoactive therapies in term and late preterm neonates with pulmonary hypertension associated with hypoxemic respiratory failure and systemic hypotension. Systemic hypotension is a common and clinically significant complication of persistent pulmonary hypertension of the newborn (PPHN) and frequently requires vasopressor support to maintain adequate systemic perfusion. Dopamine is commonly used in this setting; however, prior animal experimental and clinical data suggest it may increase pulmonary vascular resistance, potentially worsening right ventricular afterload and hypoxemia. Norepinephrine may preferentially increase systemic vascular resistance with less effect on the pulmonary circulation. This study evaluates short-term hemodynamic and oxygenation responses following initiation of dopamine or norepinephrine.
Conditions Studied
Interventions
- DRUG Norepinephrine
- DRUG Dopamine administration
Study Locations (1)
California
- UC Davis Children's Hospital - Sacramento
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2026-06-01 |
| Est. Completion | 2028-01-31 |
| Phase | Phase 4 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07322133
The ClinicalTrials.gov registry entry for NCT07322133 describes a study currently listed as recruiting, categorized as Phase 4. The registered enrollment target is 30 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of California, Davis, which has 657 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Hypotension and Shock appearing as the primary indexed condition, and to 2 interventions - of which Norepinephrine is the first listed.
NCT07322133 reports 1 study location spanning 1 distinct geographic area - top geographies include California.
Frequently Asked Questions
What is clinical trial NCT07322133 about?
NCT07322133 is a clinical study titled "Dopamine vs. Norepinephrine for Hypotension in Neonates With Pulmonary Hypertension (DONE)". This pilot randomized clinical trial compares dopamine and norepinephrine as first-line vasoactive therapies in term and late preterm neonates with pulmonary hypertension associated with hypoxemic respiratory failure and systemic hypotension. Systemic hypotension is a common and clinically significa...
What is the current status of trial NCT07322133?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 30 participants. The study started on 2026-06-01. Estimated completion is 2028-01-31.
What conditions does trial NCT07322133 study?
This clinical trial studies the following conditions: Hypotension and Shock, Hypoxemic Respiratory Failure, Pulmonary Hypertension of the Newborn (PPHN).
What interventions are being tested in trial NCT07322133?
The interventions under investigation include: Norepinephrine (DRUG), Dopamine administration (DRUG).
Who is sponsoring clinical trial NCT07322133?
This trial is sponsored by University of California, Davis, which has 657 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07322133 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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