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NCT07322133 · ClinicalTrials.gov registry record · Phase 4
Dopamine vs. Norepinephrine for Hypotension in Neonates With Pulmonary Hypertension (DONE)
A Phase 4 study of Hypotension and Shock and Hypoxemic Respiratory Failure, sponsored by University of California, Davis.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 30
- Enrollment target
- 1
- Study location
NCT07322133: Recruiting Phase 4 study of Hypotension and Shock and Hypoxemic Respiratory Failure, sponsored by University of California, Davis.
NCT07322133 is a Phase 4 study of Hypotension and Shock and Hypoxemic Respiratory Failure that is actively recruiting participants, run by University of California, Davis. The registered enrollment target is 30 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07322133, a Phase 4 study of Hypotension and Shock and Hypoxemic Respiratory Failure, is actively recruiting participants, sponsored by University of California, Davis.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
This pilot randomized clinical trial compares dopamine and norepinephrine as first-line vasoactive therapies in term and late preterm neonates with pulmonary hypertension associated with hypoxemic respiratory failure and systemic hypotension. Systemic hypotension is a common and clinically significant complication of persistent pulmonary hypertension of the newborn (PPHN) and frequently requires vasopressor support to maintain adequate systemic perfusion. Dopamine is commonly used in this setting; however, prior animal experimental and clinical data suggest it may increase pulmonary vascular resistance, potentially worsening right ventricular afterload and hypoxemia. Norepinephrine may preferentially increase systemic vascular resistance with less effect on the pulmonary circulation. This study evaluates short-term hemodynamic and oxygenation responses following initiation of dopamine or norepinephrine.
Primary Outcome
Ratio of systemic arterial pressure to pulmonary arterial pressure (SAP/PAP)
Conditions Studied
Interventions
- DRUG Norepinephrine
- DRUG Dopamine administration
Study Locations (1)
California
- UC Davis Children's Hospital - Sacramento
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2026-06-01 |
| Est. Completion | 2028-01-31 |
| Phase | Phase 4 |
What NCT07322133 shows while recruiting
NCT07322133 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (94% lower).
The record links to 3 conditions, with Hypotension and Shock appearing as the primary indexed condition, and to 2 interventions - of which Norepinephrine is the first listed.
NCT07322133 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT07322133 about?
NCT07322133 is a clinical study titled "Dopamine vs. Norepinephrine for Hypotension in Neonates With Pulmonary Hypertension (DONE)". This pilot randomized clinical trial compares dopamine and norepinephrine as first-line vasoactive therapies in term and late preterm neonates with pulmonary hypertension associated with hypoxemic respiratory failure and systemic hypotension. Systemic hypotension is a common and clinically significa...
What is the current status of trial NCT07322133?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 30 participants. The study started on 2026-06-01. Estimated completion is 2028-01-31.
What conditions does trial NCT07322133 study?
This clinical trial studies the following conditions: Hypotension and Shock, Hypoxemic Respiratory Failure, Pulmonary Hypertension of the Newborn (PPHN).
What interventions are being tested in trial NCT07322133?
The interventions under investigation include: Norepinephrine (DRUG), Dopamine administration (DRUG).
Who is sponsoring clinical trial NCT07322133?
This trial is sponsored by University of California, Davis, which has 657 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07322133 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07322133's enrollment target sits among peer trials
30 1552nd of 2000 higher than 368 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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