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NCT07298863 · ClinicalTrials.gov registry record · NA
The Effect of Hydration Status on Substrate Oxidation at Rest and During Light and Moderate Exercise
A NA study of Hydration Status and Substrate Metabolism During Exercise, sponsored by PepsiCo Global R&D.
- Recruiting
- Registry status
- NA
- Development phase
- 74
- Enrollment target
- 1
- Study location
NCT07298863: Recruiting NA study of Hydration Status and Substrate Metabolism During Exercise, sponsored by PepsiCo Global R&D.
NCT07298863 is a NA study of Hydration Status and Substrate Metabolism During Exercise that is actively recruiting participants, run by PepsiCo Global R&D. The registered enrollment target is 74 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07298863, a NA study of Hydration Status and Substrate Metabolism During Exercise, is actively recruiting participants, sponsored by PepsiCo Global R&D.
- RECRUITING
- Registry status
- NA
- Development phase
- 74 participants
- Enrollment target
- 1
- Study location
Study Summary
Metabolic flexibility is the ability to properly switch between fat and carbohydrate stores to use for energy under different conditions (rest, feeding, exercise). Impairments in metabolic flexibility, also known as metabolic inflexibility, have been suggested to be an underlying cause of metabolic disease, like type 2 diabetes. Long-term low fluid intake may increase the risk of type 2 diabetes due to insulin resistance, a form of metabolic inflexibility. Further, low fluid intake has been shown to impair the ability to switch fuel preference during exercise. While there is some evidence that low fluid intake may lead to impaired metabolic flexibility, more information is needed. Therefore, the purpose of this study is to evaluate the impact of hydration status on substrate preference at rest and during exercise at varying intensities (light and moderate). Further, we will examine whether biological sex and menstrual cycle phase impact hydration and metabolism under these same conditions.
Primary Outcome
Part 1 only. VCO2 / VO2 measured using indirect calorimetry measured by metabolic cart (Moxus or similar device) while exercising on cycle ergometer.
Conditions Studied
Interventions
- OTHER Exercise Trial
- OTHER Experimental Trial
Study Locations (1)
New York
- Gatorade Sports Science Institute - Valhalla
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 74 participants |
| Start Date | 2025-11-05 |
| Est. Completion | 2026-04-30 |
| Phase | NA |
What NCT07298863 shows while recruiting
NCT07298863 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 74 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower).
The record links to 2 conditions, with Hydration Status appearing as the primary indexed condition, and to 2 interventions - of which Exercise Trial is the first listed.
NCT07298863 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT07298863 about?
NCT07298863 is a clinical study titled "The Effect of Hydration Status on Substrate Oxidation at Rest and During Light and Moderate Exercise". Metabolic flexibility is the ability to properly switch between fat and carbohydrate stores to use for energy under different conditions (rest, feeding, exercise). Impairments in metabolic flexibility, also known as metabolic inflexibility, have been suggested to be an underlying cause of metabolic ...
What is the current status of trial NCT07298863?
This trial is currently recruiting. It is a NA study. The enrollment target is 74 participants. The study started on 2025-11-05. Estimated completion is 2026-04-30.
What conditions does trial NCT07298863 study?
This clinical trial studies the following conditions: Hydration Status, Substrate Metabolism During Exercise.
What interventions are being tested in trial NCT07298863?
The interventions under investigation include: Exercise Trial (OTHER), Experimental Trial (OTHER).
Who is sponsoring clinical trial NCT07298863?
This trial is sponsored by PepsiCo Global R&D, which has 47 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07298863 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07298863's enrollment target sits among peer trials
74 1082nd of 2000 higher than 912 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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