Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT07298057 · ClinicalTrials.gov registry record · Early Phase 1
Effect of Arestin-Enhanced SRP on Periodontal and Glycemic Outcomes in Diabetics
A Early Phase 1 study of Periodontitis, Diabetes Mellitus Type 2, sponsored by Case Western Reserve University.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 42
- Enrollment target
- 1
- Study location
NCT07298057: Recruiting Early Phase 1 study of Periodontitis, Diabetes Mellitus Type 2, sponsored by Case Western Reserve University.
NCT07298057 is a Early Phase 1 study of Periodontitis, Diabetes Mellitus Type 2 that is actively recruiting participants, run by Case Western Reserve University. The registered enrollment target is 42 participants, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (21% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07298057, a Early Phase 1 study of Periodontitis, Diabetes Mellitus Type 2, is actively recruiting participants, sponsored by Case Western Reserve University.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 42 participants
- Enrollment target
- 1
- Study location
Study Summary
Periodontitis is a prevalent chronic inflammatory disease that exacerbates systemic inflammation and poses challenges for glycemic control in diabetic patients. While scaling and root planing (SRP) remains the cornerstone of periodontal therapy, adjunctive treatments such as Arestin (minocycline microspheres) have shown promise in enhancing clinical outcomes. This study aims to evaluate the impact of adding Arestin to SRP on periodontal pocket closure, glycemic control, and systemic inflammation in diabetic patients with periodontitis.
Primary Outcome
Pocket Depth (PD ≤4 mm)
Conditions Studied
Interventions
- DRUG local antibiotic application of topical minocycline
- PROCEDURE Scaling and Root Planing
Study Locations (1)
Ohio
- Case Western Reserve University - Cleveland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 42 participants |
| Start Date | 2026-02-06 |
| Est. Completion | 2028-06 |
| Phase | Early Phase 1 |
What NCT07298057 shows while recruiting
NCT07298057 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 42 participants, a relatively small participant target, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (21% lower).
The record links to 1 condition, with Periodontitis, Diabetes Mellitus Type 2 appearing as the primary indexed condition, and to 2 interventions - of which local antibiotic application of topical minocycline is the first listed.
NCT07298057 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT07298057 about?
NCT07298057 is a clinical study titled "Effect of Arestin-Enhanced SRP on Periodontal and Glycemic Outcomes in Diabetics". Periodontitis is a prevalent chronic inflammatory disease that exacerbates systemic inflammation and poses challenges for glycemic control in diabetic patients. While scaling and root planing (SRP) remains the cornerstone of periodontal therapy, adjunctive treatments such as Arestin (minocycline mic...
What is the current status of trial NCT07298057?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 42 participants. The study started on 2026-02-06. Estimated completion is 2028-06.
What conditions does trial NCT07298057 study?
This clinical trial studies the following conditions: Periodontitis, Diabetes Mellitus Type 2.
What interventions are being tested in trial NCT07298057?
The interventions under investigation include: local antibiotic application of topical minocycline (DRUG), Scaling and Root Planing (PROCEDURE).
Who is sponsoring clinical trial NCT07298057?
This trial is sponsored by Case Western Reserve University, which has 141 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07298057 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07298057's enrollment target sits among peer trials
42 605th of 2000 higher than 1,379 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02852213 · 42 participants · Phase 1
A Single-Stage, Adaptive, Open-label, Dose Escalation Safety and Efficacy Study of AADC Deficiency in Pediatric Patients
- NCT03136146 · 42 participants · Phase 2
Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma, Burkitt Lymphoma/Leukemia, or Double-Hit Lymphoma/Leukemia
- NCT03178149 · 42 participants · Phase 1
A Study of the Safety and Tolerability of ASP7317 in Senior Adults Who Are Losing Their Clear, Sharp Central Vision Due to Geographic Atrophy Secondary to Dry Age-related Macular Degeneration
- NCT03663530 · 42 participants · NA
Circadian Misalignment and Energy Balance
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI