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RECRUITING Early Phase 1

Effect of Arestin-Enhanced SRP on Periodontal and Glycemic Outcomes in Diabetics

NCT07298057 · View on ClinicalTrials.gov ↗

Study Summary

Periodontitis is a prevalent chronic inflammatory disease that exacerbates systemic inflammation and poses challenges for glycemic control in diabetic patients. While scaling and root planing (SRP) remains the cornerstone of periodontal therapy, adjunctive treatments such as Arestin (minocycline microspheres) have shown promise in enhancing clinical outcomes. This study aims to evaluate the impact of adding Arestin to SRP on periodontal pocket closure, glycemic control, and systemic inflammation in diabetic patients with periodontitis.

Interventions

  • DRUG local antibiotic application of topical minocycline
  • PROCEDURE Scaling and Root Planing

Study Locations (1)

Ohio

  • Case Western Reserve University — Cleveland

Trial Details

FieldValue
Enrollment Target 42 participants
Start Date 2026-02-06
Est. Completion 2028-06
Phase Early Phase 1

Sponsor

Case Western Reserve University

172 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07298057

The ClinicalTrials.gov registry entry for NCT07298057 describes a study currently listed as recruiting. It is categorized as Early Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 42 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Case Western Reserve University, which has 172 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Periodontitis, Diabetes Mellitus Type 2 appearing as the primary indexed condition, and to 2 interventions — of which local antibiotic application of topical minocycline is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07298057 reports 1 study location spanning 1 distinct geographic area — top geographies include Ohio. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07298057 about?

NCT07298057 is a clinical study titled "Effect of Arestin-Enhanced SRP on Periodontal and Glycemic Outcomes in Diabetics". Periodontitis is a prevalent chronic inflammatory disease that exacerbates systemic inflammation and poses challenges for glycemic control in diabetic patients. While scaling and root planing (SRP) remains the cornerstone of periodontal therapy, adjunctive treatments such as Arestin (minocycline mic...

What is the current status of trial NCT07298057?

This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 42 participants. The study started on 2026-02-06. Estimated completion is 2028-06.

What conditions does trial NCT07298057 study?

This clinical trial studies the following conditions: Periodontitis, Diabetes Mellitus Type 2. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07298057?

The interventions under investigation include: local antibiotic application of topical minocycline (DRUG), Scaling and Root Planing (PROCEDURE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07298057?

This trial is sponsored by Case Western Reserve University, which has 172 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07298057 being conducted?

This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial