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NCT07293754 · ClinicalTrials.gov registry record · Phase 1
An Early Phase Trial of RPTR-1-201 in Advanced Solid Tumors
A Phase 1 study of Advanced Malignant Solid Tumor, sponsored by Repertoire Immune Medicines.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 150
- Enrollment target
- 1
- Study location
NCT07293754: Recruiting Phase 1 study of Advanced Malignant Solid Tumor, sponsored by Repertoire Immune Medicines.
NCT07293754 is a Phase 1 study of Advanced Malignant Solid Tumor that is actively recruiting participants, run by Repertoire Immune Medicines. The registered enrollment target is 150 participants, above the 34-participant average among 3 other Advanced Malignant Solid Tumor trials with a reported enrollment target (341% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07293754, a Phase 1 study of Advanced Malignant Solid Tumor, is actively recruiting participants, sponsored by Repertoire Immune Medicines.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 150 participants
- Enrollment target
- 1
- Study location
Study Summary
This is an early phase trial designed to evaluate the safety, tolerability, and preliminary antitumor activity of RPTR-1-201 in adults with advanced solid tumors. The trial includes dose escalation and dose expansion parts and will evaluate RPTR-1-201 as monotherapy and in combination with an anti-PD-1 monoclonal antibody.
Primary Outcome
Number of participants experiencing dose-limiting toxicities and treatment-emergent adverse events, including events considered related to RPTR-1-201, graded according to CTCAE v5.0.
Conditions Studied
Interventions
- DRUG RPTR-1-201
- DRUG PD-1 / PD-L1 monoclonal antibody
Study Locations (1)
Michigan
- START Midwest - Grand Rapids
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 150 participants |
| Start Date | 2025-12-12 |
| Est. Completion | 2029-04-15 |
| Phase | Phase 1 |
What NCT07293754 shows while recruiting
NCT07293754 is an interventional study that assigns participants to a tested intervention. The registered 150 participants enrollment target is mid-sized for trials with a published cap, above the 34-participant average among 3 other Advanced Malignant Solid Tumor trials with a reported enrollment target (341% higher).
The record links to 1 condition, with Advanced Malignant Solid Tumor appearing as the primary indexed condition, and to 2 interventions - of which RPTR-1-201 is the first listed.
NCT07293754 reports a single indexed study location in Michigan.
Frequently Asked Questions
What is clinical trial NCT07293754 about?
NCT07293754 is a clinical study titled "An Early Phase Trial of RPTR-1-201 in Advanced Solid Tumors". This is an early phase trial designed to evaluate the safety, tolerability, and preliminary antitumor activity of RPTR-1-201 in adults with advanced solid tumors. The trial includes dose escalation and dose expansion parts and will evaluate RPTR-1-201 as monotherapy and in combination with an anti-P...
What is the current status of trial NCT07293754?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 150 participants. The study started on 2025-12-12. Estimated completion is 2029-04-15.
What conditions does trial NCT07293754 study?
This clinical trial studies the following conditions: Advanced Malignant Solid Tumor.
What interventions are being tested in trial NCT07293754?
The interventions under investigation include: RPTR-1-201 (DRUG), PD-1 / PD-L1 monoclonal antibody (DRUG).
Who is sponsoring clinical trial NCT07293754?
This trial is sponsored by Repertoire Immune Medicines, which has 4 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07293754 being conducted?
This trial has 1 study location across Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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