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NCT07278323 · ClinicalTrials.gov registry record · Phase 4
Frozen Shoulder and Hormone Replacement Therapy
A Phase 4 study, sponsored by University of California, San Francisco.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 60
- Enrollment target
NCT07278323: Recruiting Phase 4 study, sponsored by University of California, San Francisco.
NCT07278323 is a Phase 4 study that is actively recruiting participants, run by University of California, San Francisco. The registered enrollment target is 60 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (88% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07278323, a Phase 4 study, is actively recruiting participants, sponsored by University of California, San Francisco.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 60 participants
- Enrollment target
Study Summary
The purpose of this study is to determine the effects of hormone replacement therapy (HRT) in addition to standard treatment on frozen shoulder symptoms in women with age-related changes to their menstrual cycle. Frozen shoulder refers to the condition a doctor diagnosed the participant with regarding shoulder pain, stiffness, and progressive loss of range of motion. Age-related menstrual cycle changes, known as perimenopause and/or menopause, refers to a change or stoppage of monthly menstrual cycles. Other symptoms participants may be experiencing include vaginal dryness, hot flashes, or night sweats. Hormone replacement therapy (HRT) refers to medicine with female hormones in it. For this study, HRT will be in the form of a patch that goes on the skin and a daily oral pill. Participants will be randomly assigned to receive either HRT plus standard care, or only standard care. Follow-up tests will be completed at 6 months of treatment to assess participant progress.
Primary Outcome
Pain in affected shoulder measured on the American Shoulder and Elbow Surgeons (ASES) shoulder function scale. Scores range from 0 to 100 with 0 indicating the lowest level of shoulder function and 100 indicating the highest level of shoulder function.
Interventions
- DRUG Hormone Replacement Therapy (HRT)
- DRUG Corticosteroid and 1%lidocain
- BEHAVIORAL physical therapy
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2026-01-15 |
| Est. Completion | 2026-12 |
| Phase | Phase 4 |
What NCT07278323 shows while recruiting
NCT07278323 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (88% lower).
The record links to 0 conditions, and to 3 interventions - of which Hormone Replacement Therapy (HRT) is the first listed.
NCT07278323 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07278323 about?
NCT07278323 is a clinical study titled "Frozen Shoulder and Hormone Replacement Therapy". The purpose of this study is to determine the effects of hormone replacement therapy (HRT) in addition to standard treatment on frozen shoulder symptoms in women with age-related changes to their menstrual cycle. Frozen shoulder refers to the condition a doctor diagnosed the participant with regardi...
What is the current status of trial NCT07278323?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 60 participants. The study started on 2026-01-15. Estimated completion is 2026-12.
What interventions are being tested in trial NCT07278323?
The interventions under investigation include: Hormone Replacement Therapy (HRT) (DRUG), Corticosteroid and 1%lidocain (DRUG), physical therapy (BEHAVIORAL).
Who is sponsoring clinical trial NCT07278323?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07278323's enrollment target sits among peer trials
60 1125th of 2000 higher than 799 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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