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RECRUITING Phase 2

Study to Assess the Effects of Angiopoietin-like Protein 3 (ANGPTL3) Inhibition in Adult Participants With Diabetic Kidney Disease

NCT07271186 · View on ClinicalTrials.gov ↗

Study Summary

This study is researching experimental drugs called ALN-ANG3 and evinacumab (called "study drugs"). The study is focused on participants who have diabetic kidney disease. The aim of the study is to see how safe and effective the study drugs are. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times

Interventions

  • DRUG ALN-ANG3
  • DRUG Evinacumab
  • DRUG ALN-ANG3 placebo
  • DRUG Evinacumab placebo

Study Locations (20)

Florida

  • D&H Doral Research Center — Doral
  • AGA Clinical Trials — Hialeah
  • Convenient Medical Center — Hialeah
  • Elixia Hollywood — Hollywood
  • D&H Pompano Research Center — Margate
  • LCC Medical Research Institute — Miami
  • D&H National Research Centers, Inc — Miami
  • Regenerate Primary Medical Research, LLC — Miami
  • Ocean Blue Medical Research Center - Internal Medicine — Miami Springs
  • Innovia Research Center — Miramar
  • Bolanos Clinical Research — Pembroke Pines
  • D&H Tamarac Research Center — Tamarac
  • Metabolic Research Institute — West Palm Beach

California

  • Amicis Research Center — Northridge
  • Central Coast Nephrology — Salinas
  • North America Research Institute — San Dimas
  • Amicis Research Center — Santa Clarita
  • Amicis Research Center — Valencia

Arkansas

  • Applied Research Center of Arkansas — Little Rock

Illinois

  • Research by Design, LLC - Internal Medicine — Chicago

Trial Details

FieldValue
Enrollment Target 270 participants
Start Date 2026-01-09
Est. Completion 2028-04-07
Phase Phase 2

Sponsor

Regeneron Pharmaceuticals

290 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07271186

The ClinicalTrials.gov registry entry for NCT07271186 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 270 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Regeneron Pharmaceuticals, which has 290 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Diabetic Kidney Disease (DKD) appearing as the primary indexed condition, and to 4 interventions — of which ALN-ANG3 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07271186 reports 20 study locations spanning 4 distinct geographic areas — top geographies include Florida, California, Arkansas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07271186 about?

NCT07271186 is a clinical study titled "Study to Assess the Effects of Angiopoietin-like Protein 3 (ANGPTL3) Inhibition in Adult Participants With Diabetic Kidney Disease". This study is researching experimental drugs called ALN-ANG3 and evinacumab (called "study drugs"). The study is focused on participants who have diabetic kidney disease. The aim of the study is to see how safe and effective the study drugs are. The study is looking at several other research quest...

What is the current status of trial NCT07271186?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 270 participants. The study started on 2026-01-09. Estimated completion is 2028-04-07.

What conditions does trial NCT07271186 study?

This clinical trial studies the following conditions: Diabetic Kidney Disease (DKD). These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07271186?

The interventions under investigation include: ALN-ANG3 (DRUG), Evinacumab (DRUG), ALN-ANG3 placebo (DRUG), Evinacumab placebo (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07271186?

This trial is sponsored by Regeneron Pharmaceuticals, which has 290 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07271186 being conducted?

This trial has 20 study locations across Arkansas, California, Florida, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial