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NCT07228208 · ClinicalTrials.gov registry record · NA
Role of Endothelial Dysfunction on Exercise Pressor Reflex in Type 2 Diabetes
A NA study, sponsored by Medical College of Wisconsin.
- Not yet
- Registry status
- NA
- Development phase
- 40
- Enrollment target
NCT07228208: Clinical Trial NA study, sponsored by Medical College of Wisconsin.
NCT07228208 is a NA study that has not yet begun recruiting, run by Medical College of Wisconsin. The registered enrollment target is 40 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07228208, a NA study, has not yet begun recruiting, sponsored by Medical College of Wisconsin.
- NOT YET RECRUITING
- Registry status
- NA
- Development phase
- 40 participants
- Enrollment target
Study Summary
Exaggerated blood pressure responses to exercise in individuals with Type 2 Diabetes significantly increase the risk of heart attack, stroke, and cardiovascular death, while also limiting exercise capacity and therapeutic benefits of physical activity. This research will determine whether impaired blood vessel function and excessive cellular damage from oxygen-containing molecules cause these dangerous blood pressure responses during exercise. The findings will establish whether targeting cellular antioxidant systems represents a new therapeutic approach to improve exercise tolerance and reduce cardiovascular risk in t Americans living with diabetes.
Primary Outcome
Change in mean arterial pressure is measured in response to handgrip exercise and post-exercise circulatory occlusion
Interventions
- DIETARY_SUPPLEMENT Placebo
- DIETARY_SUPPLEMENT MitoQ (mitoquinol mesylate)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2026-09-01 |
| Est. Completion | 2031-12-31 |
| Phase | NA |
What is known before NCT07228208 opens enrollment
NCT07228208 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT07228208 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07228208 about?
NCT07228208 is a clinical study titled "Role of Endothelial Dysfunction on Exercise Pressor Reflex in Type 2 Diabetes". Exaggerated blood pressure responses to exercise in individuals with Type 2 Diabetes significantly increase the risk of heart attack, stroke, and cardiovascular death, while also limiting exercise capacity and therapeutic benefits of physical activity. This research will determine whether impaired b...
What is the current status of trial NCT07228208?
This trial is currently not yet recruiting. It is a NA study. The enrollment target is 40 participants. The study started on 2026-09-01. Estimated completion is 2031-12-31.
What interventions are being tested in trial NCT07228208?
The interventions under investigation include: Placebo (DIETARY_SUPPLEMENT), MitoQ (mitoquinol mesylate) (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT07228208?
This trial is sponsored by Medical College of Wisconsin, which has 447 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07228208's enrollment target sits among peer trials
40 1447th of 2000 higher than 465 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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