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NCT07226245 · ClinicalTrials.gov registry record · Phase 4
Methadone Pharmacokinetics in Cardiac Surgery
A Phase 4 study, sponsored by Wake Forest University Health Sciences.
- Not yet
- Registry status
- Phase 4
- Development phase
- 69
- Enrollment target
NCT07226245: Clinical Trial Phase 4 study, sponsored by Wake Forest University Health Sciences.
NCT07226245 is a Phase 4 study that has not yet begun recruiting, run by Wake Forest University Health Sciences. The registered enrollment target is 69 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (87% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07226245, a Phase 4 study, has not yet begun recruiting, sponsored by Wake Forest University Health Sciences.
- NOT YET RECRUITING
- Registry status
- Phase 4
- Development phase
- 69 participants
- Enrollment target
Study Summary
Cardiac surgery frequently leads to significant postoperative pain, with multiple different drug regimens being utilized (both opioid and non-opioid) in an attempt to alleviate this surgical pain. Methadone is currently one of the drugs that is being utilized to help control the pain. It can be given during and/or after surgery. This study hopes to identify the optimal dose of methadone to use to treat this surgical pain.
Interventions
- DRUG Single dose of methadone
- DRUG Split dose of methadone
- DRUG Balanced split dose of methadone
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 69 participants |
| Start Date | 2026-09 |
| Est. Completion | 2026-12-30 |
| Phase | Phase 4 |
What is known before NCT07226245 opens enrollment
NCT07226245 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 69 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (87% lower).
The record links to 0 conditions, and to 3 interventions - of which Single dose of methadone is the first listed.
NCT07226245 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07226245 about?
NCT07226245 is a clinical study titled "Methadone Pharmacokinetics in Cardiac Surgery". Cardiac surgery frequently leads to significant postoperative pain, with multiple different drug regimens being utilized (both opioid and non-opioid) in an attempt to alleviate this surgical pain. Methadone is currently one of the drugs that is being utilized to help control the pain. It can be give...
What is the current status of trial NCT07226245?
This trial is currently not yet recruiting. It is a Phase 4 study. The enrollment target is 69 participants. The study started on 2026-09. Estimated completion is 2026-12-30.
What interventions are being tested in trial NCT07226245?
The interventions under investigation include: Single dose of methadone (DRUG), Split dose of methadone (DRUG), Balanced split dose of methadone (DRUG).
Who is sponsoring clinical trial NCT07226245?
This trial is sponsored by Wake Forest University Health Sciences, which has 1,140 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07226245's enrollment target sits among peer trials
69 1070th of 2000 higher than 925 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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