Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT07224737 · ClinicalTrials.gov registry record
Liquid Biopsy Using Exosomal miRNA Enables Risk Stratification of Potential Metastasis in Patients With Intrahepatic Cholangiocarcinoma.
A clinical trial, sponsored by City of Hope Medical Center.
- Completed
- Registry status
- 230
- Enrollment target
NCT07224737: Completed study, sponsored by City of Hope Medical Center.
NCT07224737 is a clinical trial that has completed, run by City of Hope Medical Center. The registered enrollment target is 230 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07224737 has completed, sponsored by City of Hope Medical Center.
- COMPLETED
- Registry status
- 230 participants
- Enrollment target
Study Summary
Occult metastasis at the time of surgery is a major driver of poor outcomes in intrahepatic cholangiocarcinoma (ICC), yet reliable preoperative biomarkers to identify such patients are lacking. The EXOMIC study aims to develop and validate a circulating exosomal microRNA (exo-miRNA)-based liquid biopsy assay to detect occult metastasis preoperatively in patients with resectable ICC.
Primary Outcome
The time period from surgery to recurrence of ICC.
Interventions
- DIAGNOSTIC_TEST EXOMIC small RNA sequencing
- DIAGNOSTIC_TEST EXOMIC assay (qRT-PCR validation)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 230 participants |
| Start Date | 2024-06-21 |
| Est. Completion | 2026-02-18 |
What the finished NCT07224737 record still lists
NCT07224737 is an observational study that tracks outcomes without assigning an intervention. The registered 230 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 2 interventions - of which EXOMIC small RNA sequencing is the first listed.
NCT07224737 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07224737 about?
NCT07224737 is a clinical study titled "Liquid Biopsy Using Exosomal miRNA Enables Risk Stratification of Potential Metastasis in Patients With Intrahepatic Cholangiocarcinoma.". Occult metastasis at the time of surgery is a major driver of poor outcomes in intrahepatic cholangiocarcinoma (ICC), yet reliable preoperative biomarkers to identify such patients are lacking. The EXOMIC study aims to develop and validate a circulating exosomal microRNA (exo-miRNA)-based liquid bio...
What is the current status of trial NCT07224737?
This trial is currently completed. The enrollment target is 230 participants. The study started on 2024-06-21. Estimated completion is 2026-02-18.
What interventions are being tested in trial NCT07224737?
The interventions under investigation include: EXOMIC small RNA sequencing (DIAGNOSTIC_TEST), EXOMIC assay (qRT-PCR validation) (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT07224737?
This trial is sponsored by City of Hope Medical Center, which has 582 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02710253 · 230 participants · Phase 2
Salvage Radiation Therapy in Treating Patients With Metastatic Cancer That Has Progressed After Systemic Immunotherapy
- NCT02777879 · 230 participants
Lung Microbiome and Inflammation in Early COPD
- NCT03824483 · 230 participants · Phase 2
Study of Zanubrutinib, Obinutuzumab, and Venetoclax in Patients With Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL)
- NCT03833622 · 230 participants · NA
Shared Decision Making to Improve Goals of Care in the ED
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI