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NCT07223710 · ClinicalTrials.gov registry record · Phase 1
Improving Walking After Spinal Cord Injury
A Phase 1 study, sponsored by Shirley Ryan AbilityLab.
- Not yet
- Registry status
- Phase 1
- Development phase
- 20
- Enrollment target
NCT07223710: Clinical Trial Phase 1 study, sponsored by Shirley Ryan AbilityLab.
NCT07223710 is a Phase 1 study that has not yet begun recruiting, run by Shirley Ryan AbilityLab. The registered enrollment target is 20 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (67% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07223710, a Phase 1 study, has not yet begun recruiting, sponsored by Shirley Ryan AbilityLab.
- NOT YET RECRUITING
- Registry status
- Phase 1
- Development phase
- 20 participants
- Enrollment target
Study Summary
Locomotor recovery is one of the most important goals of individuals with spinal cord injury (SCI). Ambulatory deficits severely impact daily functions resulting in lower quality of life for people living with paralysis due to SCI. Although studies have shown that locomotor training improves locomotor function in people with chronic SCI, the benefits remain limited. Our overall hypothesis is that we can engage additional descending motor pathways, such as the reticulospinal tract (RST), to improve locomotor function in humans with chronic incomplete SCI. In this study we propose to test the effects of a novel intervention that uses repeated paired loud auditory and electrical stimulation of muscle afferents combined with locomotor training on walking speed and voluntary muscle strength.
Primary Outcome
This standardized test assesses walking speed in meters per second over a short duration.
Interventions
- DEVICE Sham stimulation
- BEHAVIORAL Locomotor Training
- DEVICE Paired Associative Stimulation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2025-11-15 |
| Est. Completion | 2026-07-30 |
| Phase | Phase 1 |
What is known before NCT07223710 opens enrollment
NCT07223710 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (67% lower).
The record links to 0 conditions, and to 3 interventions - of which Sham stimulation is the first listed.
NCT07223710 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07223710 about?
NCT07223710 is a clinical study titled "Improving Walking After Spinal Cord Injury". Locomotor recovery is one of the most important goals of individuals with spinal cord injury (SCI). Ambulatory deficits severely impact daily functions resulting in lower quality of life for people living with paralysis due to SCI. Although studies have shown that locomotor training improves locomot...
What is the current status of trial NCT07223710?
This trial is currently not yet recruiting. It is a Phase 1 study. The enrollment target is 20 participants. The study started on 2025-11-15. Estimated completion is 2026-07-30.
What interventions are being tested in trial NCT07223710?
The interventions under investigation include: Sham stimulation (DEVICE), Locomotor Training (BEHAVIORAL), Paired Associative Stimulation (DEVICE).
Who is sponsoring clinical trial NCT07223710?
This trial is sponsored by Shirley Ryan AbilityLab, which has 138 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07223710's enrollment target sits among peer trials
20 1629th of 2000 higher than 285 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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