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NCT07221825 · ClinicalTrials.gov registry record · NA
Low-Count Quantitative SPECT for Men Treated With Radium-223
A NA study, sponsored by Washington University School of Medicine.
- Not yet
- Registry status
- NA
- Development phase
- 38
- Enrollment target
NCT07221825 is a NA study that has not yet begun recruiting, run by Washington University School of Medicine. The registered enrollment target is 38 participants.
The verdict
NCT07221825, a NA study, has not yet begun recruiting, sponsored by Washington University School of Medicine.
- NOT YET RECRUITING
- Registry status
- NA
- Development phase
- 38 participants
- Enrollment target
Study Summary
Internal radiotherapies (radiolabeled molecules that are systemically administered and localize to sites of disease) provide cancer-ablating doses to diseased cells while sparing adjacent normal tissues. \[223Ra\]RaCl2 (Xofigo) is the first FDA-approved alpha-particle emitting radiopharmaceutical therapy (αRPT), providing a survival benefit for men with bone metastatic castration-resistant prostate cancer. Systemically administered radiotherapies distribute throughout the patient, accumulating to unknown levels at sites of disease and in radiosensitive vital organs. The whole-body distribution means that absorbed doses in the patient extend far beyond a pre-defined treatment field. There is a lack of information about αRPT distribution and localization, and this confounds treatment monitoring, complicates dose and schedule personalization, and impedes drug development. Single-photon emission computed tomography (SPECT) imaging offers a mechanism to quantify uptake; however, αRPT administered activities are significantly lower than those used with diagnostic procedures, which presents a challenge for quantitation with conventional methods. Preliminary research shows that low-count quantitative SPECT (LC-QSPECT) imaging demonstrates reliable quantitation of regional uptake for αRPTs. The purpose of this study is to demonstrate the feasibility, tolerability and performance of LC-QSPECT imaging.
Interventions
- DEVICE Low-count quantitative single-photon emission computed tomography imaging
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 38 participants |
| Start Date | 2026-07-01 |
| Est. Completion | 2028-07-31 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07221825
The ClinicalTrials.gov registry entry for NCT07221825 describes a study currently listed as not yet recruiting, categorized as NA. The registered enrollment target is 38 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Washington University School of Medicine, which has 1,502 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Low-count quantitative single-photon emission computed tomography imaging is the first listed.
NCT07221825 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT07221825 about?
NCT07221825 is a clinical study titled "Low-Count Quantitative SPECT for Men Treated With Radium-223". Internal radiotherapies (radiolabeled molecules that are systemically administered and localize to sites of disease) provide cancer-ablating doses to diseased cells while sparing adjacent normal tissues. \[223Ra\]RaCl2 (Xofigo) is the first FDA-approved alpha-particle emitting radiopharmaceutical th...
What is the current status of trial NCT07221825?
This trial is currently not yet recruiting. It is a NA study. The enrollment target is 38 participants. The study started on 2026-07-01. Estimated completion is 2028-07-31.
What interventions are being tested in trial NCT07221825?
The interventions under investigation include: Low-count quantitative single-photon emission computed tomography imaging (DEVICE).
Who is sponsoring clinical trial NCT07221825?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
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