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NCT07221019 · ClinicalTrials.gov registry record · Phase 4
Single Shot Exparel vs Catheters in Lower Extremity Trauma
A Phase 4 study of Fracture and Fracture Dislocation of Ankle Joint, sponsored by George Washington University.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 90
- Enrollment target
- 1
- Study location
NCT07221019 is a Phase 4 study of Fracture and Fracture Dislocation of Ankle Joint that is actively recruiting participants, run by George Washington University. The registered enrollment target is 90 participants, below the 4,692-participant average among 9 other Fracture trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state.
The verdict
NCT07221019, a Phase 4 study of Fracture and Fracture Dislocation of Ankle Joint, is actively recruiting participants, sponsored by George Washington University.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 90 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will compare the use of single-shot Exparel, a long-acting local anesthestic, with the use of catheters that deliver a continuous flow of the short-acting local anesthetic ropivacaine. The comparison will be done in patients who receive preoperative adductor and sciatic nerve blocks prior to orthopedic surgery for traumatic lower extremity injury. The patients' pain will then be monitored for up to 72 hours after injection, measuring every 12 hours after injection until the 72-hour mark. Opioid consumption (measured in morphine milligram equivalents) will also be tracked over this time period.
Conditions Studied
Interventions
- DRUG Bupivacaine
- DRUG Exparel + Bupivacaine
Study Locations (1)
District of Columbia
- The George Washington University Hospital - Washington D.C.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 90 participants |
| Start Date | 2025-09-12 |
| Est. Completion | 2029-08-11 |
| Phase | Phase 4 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07221019
The ClinicalTrials.gov registry entry for NCT07221019 describes a study currently listed as recruiting, categorized as Phase 4. The registered enrollment target is 90 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 4,692-participant average among 9 other Fracture trials with a reported enrollment target (98% lower). The listed sponsor is George Washington University, which has 133 total studies on file at ClinicalTrials.gov.
The record links to 5 conditions, with Fracture appearing as the primary indexed condition, and to 2 interventions - of which Bupivacaine is the first listed.
NCT07221019 reports 1 study location spanning 1 distinct geographic area - top geographies include District of Columbia.
Frequently Asked Questions
What is clinical trial NCT07221019 about?
NCT07221019 is a clinical study titled "Single Shot Exparel vs Catheters in Lower Extremity Trauma". This study will compare the use of single-shot Exparel, a long-acting local anesthestic, with the use of catheters that deliver a continuous flow of the short-acting local anesthetic ropivacaine. The comparison will be done in patients who receive preoperative adductor and sciatic nerve blocks prior...
What is the current status of trial NCT07221019?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 90 participants. The study started on 2025-09-12. Estimated completion is 2029-08-11.
What conditions does trial NCT07221019 study?
This clinical trial studies the following conditions: Fracture, Fracture Dislocation of Ankle Joint, Fracture Leg, Fracture Femur, Fracture Lower Leg.
What interventions are being tested in trial NCT07221019?
The interventions under investigation include: Bupivacaine (DRUG), Exparel + Bupivacaine (DRUG).
Who is sponsoring clinical trial NCT07221019?
This trial is sponsored by George Washington University, which has 133 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07221019 being conducted?
This trial has 1 study location across District of Columbia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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